US4153696A
Expired / Lapsed
US
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Dihydroxyphenylethylaminoalkyl theophyllines
Assignee: Evonik Operations GmbH
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Filing: 1977-11-29
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Granted: 1979-05-08
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Expires: 1997-11-29
Abstract
Abstract There are prepared compounds of the formula ##STR1## in which T is the theophyllin-7-yl group and alk is a straight or branched alkylene chain with 2 to 4 carbon atoms and salts thereof. The compounds promote circulation and produce a marked and persistent increase in renal circulation.
Inventors
- 👤 Axel Kleemann
- 👤 Karl H. Klingler
- 👤 Ansgar VON Schlichtegroll
- 👤 Fritz Stroman
- 👤 Klaus Thiemer
- 👤 Erik Westermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:12
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61P; A61P9/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
31 words
A compound corresponding to the general formula ##STR6## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 3 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
31 words
A compound corresponding to the general formula ##STR6## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 3 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
13 words
A compound according to claim 1 in the form of the free base.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 in the form of a pharmaceutically acceptable salt.
Claim 5
Independent Claim
55 words
A method of increasing renal circulation in a mammal comprising administering to the mammal an effective amount to increase renal circulation of a compound corresponding to the general formula ##STR7## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 6
Independent Claim
55 words
A method of increasing renal circulation in a mammal comprising administering to the mammal an effective amount to increase renal circulation of a compound corresponding to the general formula ##STR7## in which T is the theophyllin-7-yl radical and alk is an alkylene chain with 2 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
11 words
A method according to claim 4 wherein the compound is 7-{3-[3,4,-dihydroxyphenyl)-ethylamino]-propyl}-theophylline.
Claim 8
Dependent Claim
10 words
A method according to claim 4 wherein alk is ##STR8##
Claim 9
Dependent Claim
11 words
A method according to claim 6 wherein the compound is 7-{2-[2-(3,4-dihydroxyphenyl)-ethylamino]-ethyl}-theophylline.
Claim 10
Dependent Claim
9 words
A compound according to claim 6 which is 7-{3-[2-(3,4-dihydroxyphenyl)-ethylamino]-propyl}-theophylline.
Claim 11
Dependent Claim
11 words
A method according to claim 6 wherein the compound is 7-{3-[2-(3,4-dihydroxyphenyl)-ethylamino]-butyl}-theophylline.
Claim 12
Dependent Claim
20 words
A method according to claim 4 wherein there is administered orally at least 0.1 mg/kg body weight of the mammal.
Claim 13
Dependent Claim
20 words
A method according to claim 4 wherein there is administered intravenously at least 0.001 mg/kg body weight of the mammal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-07 | 1982-11-06 | 1983-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-07 | 1986-11-06 | 1987-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-07 | 1990-11-06 | 1991-05-08 | $7700.00 | Window Closed / Lapsed |