US4152434A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Morpholine containing imidzo[4,5-b]pyridines and use thereof
Assignee: Hexachimie SA
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Filing: 1978-08-14
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Granted: 1979-05-01
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Expires: 1998-08-14
Abstract
Abstract Morpholine derivatives of the formula: ##STR1## in which Z is CH or N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R 1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts have interesting therapeutic properties, especially on the central nervous system.
Inventors
- 👤 Bernard Schwiesguth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:01
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
65 words
Morpholine derivatives of the formula: ##STR5## in which Z is N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R 1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
65 words
Morpholine derivatives of the formula: ##STR5## in which Z is N, Y is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, R is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, benzyl, or phenyl, and R 1 is hydrogen or benzyl, and their non-toxic pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
10 words
4-Benzyl-2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine hydrochloride and its non-toxic pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
10 words
4-Benzyl-2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine hydrochloride and its non-toxic pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
10 words
2-(1-Phenyl-2,3-dihydro-imidazo(4,5-b)-pyridin-2-on-3-yl-methyl)-morpholine maleate and its non-toxic pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
10 words
2-(1-Phenyl-2,3-dihydro-imidazo(4,5-b)-pyridin-2-on-3-yl-methyl)-morpholine maleate and its non-toxic pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
27 words
A pharmaceutical composition comprising, in association with a therapeutically administrable vehicle or excipient a compound as claimed in claim 1 in an amount effective as an anti-depressant.
Claim 8
Dependent Claim
25 words
A method for the therapeutical treatment of depression which comprises the administration of an antidepressant effective amount of a compound as defined by claim 1.
References Cited (Backward Citations)
US3719683A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-30 | 1982-10-30 | 1983-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-30 | 1986-10-30 | 1987-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-30 | 1990-10-30 | 1991-05-01 | $7700.00 | Window Closed / Lapsed |