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US4152431A
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US
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Compositions and method of use
Assignee: William H Rorer Inc
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Filing: 1978-04-27
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Granted: 1979-05-01
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Expires: 1998-04-27
Abstract
Abstract The present invention relates to a method of topically treating inflammation in warm blooded animals which comprises administering to a warm blooded animal in need of such treatment an effective amount of bis-(2-pyridyl-1-oxide) disulfide and/or the adducts of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY.sub.t (I) wherein M represents a member selected from the group consisting of zinc, iron, magnesium, tin, cadmium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic or organic acid and t is either 1 or 2.
Inventors
- 👤 Robert W. Klein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/57; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4906; A61K8/4933; A61K8/63; A61K9/00; A61K9/06; A61Q; A61Q19/00; Y; Y10; Y10S; Y10S424/00; Y10S424/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
90 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a compound selected from the group consisting of bis-(2-pyridyl-1-oxide) disulfide and the adducts of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY.sub.t wherein M represents a member selected from the group consisting of zinc, iron, magnesium, tin, cadmium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic or organic acid and t is either 1 or 2.
Claim 2
Independent Claim
90 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a compound selected from the group consisting of bis-(2-pyridyl-1-oxide) disulfide and the adducts of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY.sub.t wherein M represents a member selected from the group consisting of zinc, iron, magnesium, tin, cadmium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic or organic acid and t is either 1 or 2.
Claim 3
Independent Claim
87 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a compound selected from the group consisting of bis-(2-pyridyl-1-oxide) disulfide and the adducts of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY .sub.t wherein M represents a member selected from the group consisting of magnesium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic or organic acid and t is either 1 or 2.
Claim 4
Independent Claim
87 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a compound selected from the group consisting of bis-(2-pyridyl-1-oxide) disulfide and the adducts of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY .sub.t wherein M represents a member selected from the group consisting of magnesium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic or organic acid and t is either 1 or 2.
Claim 5
Dependent Claim
16 words
The method of claim 2, wherein M is magnesium, Y is sulfate and t is 1.
Claim 6
Dependent Claim
16 words
The method of claim 2, wherein M is calcium, Y is chloride and t is 2.
Claim 7
Dependent Claim
12 words
The method of claim 2, wherein M is calcium, magnesium or barium.
Claim 8
Dependent Claim
84 words
The method of claim 2, wherein the compound is selected from the group consisting of (C 5 H 4 NOS) 2 , (C 5 H 4 NOS) 2 · CaCl 2 , (C 5 H 4 NOS) 2 MgSO 4 · 3H 2 O, (C 5 H 4 NOS) 2 SrCl 2 , (C 5 H 4 NOS) 2 SrBr 2 , (C 5 H 4 NOS) 2 Ca(NO 3 ) 2 and (C 5 H 4 NOS) 2 Ba(ClO 3 ) 2 .
Claim 9
Dependent Claim
18 words
The method of claim 2, wherein said warm blooded animal is treated for skin conditions requiring anti-inflammatory treatment.
Claim 10
Dependent Claim
19 words
The method of claim 7, wherein said skin condition is contact dermatitis, seborrheic dermatitis, atopic dermatitis or neuro dermatitis.
Claim 11
Dependent Claim
10 words
The method of claim 2, wherein said adducts are water-soluble.
Claim 12
Dependent Claim
19 words
The method of claim 2, wherein Y is selected from the group consisting of halides, sulfates, nitrates and acetates.
Claim 13
Dependent Claim
19 words
The method of claim 2, wherein said warm blooded animal is treated for erythema, arthritis, tendinitis or sciatic pain.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-30 | 1982-10-30 | 1983-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-30 | 1986-10-30 | 1987-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-30 | 1990-10-30 | 1991-05-01 | $7700.00 | Window Closed / Lapsed |