Orally administered composition containing organic amine-organic acid addition salt for reducing excessive secretion of sebum on human skin and scalp

Claim 1

A composition for oral administration to a human having a scalp or skin characterized by an excessive secretion of sebum to improve the condition thereof by reducing said excessive secretion of sebum comprising in admixture with a solid ingestible carrier from 0.75 to 20 weight percent of a non-toxic active compound selected from the group consisting of: 5-amino-3-thia hexanedioate of 2-benzylthio-ethylammonium, 5-acetamido-3-thia-hexanedioate of di-(2-benzyl-thioethylammonium), 5-amino-3-thia hexanedioate of 2-(3-alanylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-methylthioethylammonium, 5-amino-3-thia hexanedioate of 3-benzylthiopropylammonium, 2-amino-4-thia heptanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2,2-dimethoxyethylthio)-ethylammonium, 2-acetamido-3-benzylthio-propionate of 2-methylthioethylammonium, 5-benzamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-toluenesulfonamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 5-p-acetamidobenzenesulfonamido-3-thia-hexanedioate of di-(2-benzylthioethylammonium), 5-p-acetamidobenzamido-3-thia-hexanedioate of di(2-benzylthioethylammonium), 2-acetamido-4-thia-heptanedioate of di(2-methylthio-ethylammonium), 2-amino-4-thia decanedioate of 2-benzylthioethylammonium, 5-amino-3-thia hexanedioate of 2-benzylthiopropylammonium, 5-amino-3-thia hexanedioate of 2-benzylthio-2-methylpropylammonium, 5-amino-3-thia hexanedioate of 2-phenylthioethylammonium, 5-amino-3-thia hexanedioate of 2-t-butylthioethylammonium, 5-amino-3-thia hexanedioate of 2-tritylthioethylammonium, 5-amino-3-thia hexanedioate of 2-(2-butenylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(2-hydroxyethylthio)ethylammonium, 5-amino-3-thia hexanedioate of 2-(2,3-dihydroxypropylthio) ethylammonium, 3-benzylthio-2-phenylacetamido propionate of 2-methylthioethylammonium, 2-acetamido-3-tritylthiopropionate of 2-methylthioethylammonium, 2-acetamido-3-benzhydrylthio propionate of 2-methylthioethylammonium, 5-amino-3-thia hexanedioate of 6-methanesulfonamido-6-ethoxy carbonyl-4-thia hexylammonium, 2-acetamido-4-thia-nonanedioate of 2,2'-thio bis (ethylammonium), di-(β-benzylthioethylammonium) 5-p-acetamido-3-thiahexanedioate, 5-amino-3-thia acid hexanedioate of 2-octadecylthio ethylammonium, 2-amino-4-thia heptanedioate of 2-undecenylthio ethylammonium, 2-amino-4-thia nonanedioate of 2-(3-hydroxypropylthio) ethylammonium, di-(5-amino-3-thia hexanedioate) of 3-thia-1,6-hexanediammonium, 2-amino-4-thia octanedioate of 2-(β-ureido ethylthio)ethylammonium, 5-amino-3-thia hexanedioate of 2-(3-methanesulfonamido propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-phenylbenzylthio) ethylammonium, 5-tetradecanamido-3-thia hexanedioate of di(2-β-hydroxyethyl thio ethylammonium), 2-crotonamido-4-thia heptanedioate of di(2-tertiobutylthio ethylammonium), 2-butanesulfonamido-4-thia octanedioate of 2,2'-(2,3-dihydroxy-1,4-butanediyl dithio) diethylammonium, 2-formamido-3-(propyn-2-ylthio) propionate of 3-(1-naphthyl thio) propylammonium, 3-methylthio-2-trifluoroacetamido propionate of 2-oleylthio ethylammonium, 2-o-chlorobenzylthiomethyl-3-aza-4-oxo heptanedioate of 5,5'-sulfonyl bis (3-thia pentylammonium), 2-acetamido-3-p-methylthiophenylthio propionate of 2-(2,4,6-trimethyl benzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(3,4-dichlorobenzylthio) ethylammonium, 2-butyramido-3-isopropylthio propionate of 2-(2,6-dichlorobenzylthio) ethylammonium, 2-acetamido-3-(3-alanylthio) propionate of 2-m-fluorobenzylthio ethylammonium, 6-amino-3-thia heptanedioate of 2-p-dimethylaminobenzylthio ethylammonium, 2-hexanamido-di-(p-methoxyphenyl)-3-methylthio propionate of 2-(2,3-dihydroxy propylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(o-chlorobenzylthio) ethylammonium, 5-amino-3-thia hexanedioate of 2-(p-bromobenzylthio) ethylammonium, 5-acetamido-3-thia hexanedioate of di-2-(2,4-dichlorobenzylthio) ethylammonium, and 2-acetamido-3-p-fluorobenzylthio propionate of 2-hexadecylthio ethylammonium.