US4151277A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-glycosidic theophylline-sugar derivatives
Assignee: BASF SE
•
Filing: 1978-03-13
•
Granted: 1979-04-24
•
Expires: 1998-03-13
Abstract
Abstract Hypolipemic non-glycosidic theophylline-sugar compounds having the formula <IMAGE> are disclosed, as are a method for making them and methods and compositions for treating hyperlipemia with the compounds.
Inventors
- 👤 Hans P. Albrecht
- 👤 Ludwig Friedrich
- 👤 Frank Zimmermann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:31
CPC Classifications
C; C07; C07H; C07H9/00; C07H9/02; C07H9/04; A; A61; A61P; A61P3/00; A61P3/06; C07H13/00; C07H13/02; C07H13/10
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
89 words
A theophylline-sugar compound of the formula ##STR4## wherein R 1 taken alone is alkyl having 1 to 4 carbon atoms, R 2 taken alone is hydrogen, aliphatic acyl having 1-4 carbon atoms, benzoyl, nicotinoyl, or clofibrinyl; wherein any two adjacent R 2 groups taken together or R 1 and adjacent R 2 taken together may also be an acetal or ketal protective group having up to 5 carbon atoms; and wherein a and b are the integer 0 or 1 but a and b may not both be 1.
Claim 2
Dependent Claim
89 words
A theophylline-sugar compound of the formula ##STR4## wherein R 1 taken alone is alkyl having 1 to 4 carbon atoms, R 2 taken alone is hydrogen, aliphatic acyl having 1-4 carbon atoms, benzoyl, nicotinoyl, or clofibrinyl; wherein any two adjacent R 2 groups taken together or R 1 and adjacent R 2 taken together may also be an acetal or ketal protective group having up to 5 carbon atoms; and wherein a and b are the integer 0 or 1 but a and b may not both be 1.
Claim 3
Dependent Claim
12 words
A compound as in claim 1 wherein said protective group is isopropylidene.
Claim 4
Dependent Claim
9 words
A compound as in claim 1 which is methyl-6-desoxy-6-(theophyll-7-yl)-2,3,4-tri-O-nicotinoyl-α-D-glucopyranoside.
Claim 5
Dependent Claim
9 words
A compound as in claim 1 which is methyl-6-desoxy-6-(theophyll-7-yl)-2,3,4-tri-O-clofibrinyl-α-D-glucopyranoside.
Claim 6
Dependent Claim
9 words
A compound as in claim 1 which is methyl-6-desoxy-6-(theophyll-7-yl)-2,3,4-tri-O-acetyl-α-D-glucopyranoside.
Claim 7
Dependent Claim
9 words
A compound as in claim 1 which is methyl-6-desoxy-6-(theophyll-7-yl)-α-D-glucopyranoside.
Claim 8
Dependent Claim
9 words
A compound as in claim 1 which is 6-desoxy-6-(theophyll-7-yl)-1,2-O-isopropyliden-3,5-di-O-nicotinoyl-.alpha.-D-glucofuranoside.
Claim 9
Dependent Claim
9 words
A compound as in claim 1 which is 6-desoxy-6-(theophyll-7-yl)-1,2-O-isopropyliden-α-D-glucofuranoside.
Claim 10
Dependent Claim
9 words
A compound as in claim 1 which is 6-desoxy-6-(theophyll-7-yl)-3,5-di-O-clofibrinyl-1,2-O-isopropyliden-.alpha.-D-glucofuranoside.
Claim 11
Dependent Claim
9 words
A compound as in claim 1 which is methyl-5-desoxy-5-(theophyll-7-yl)-β-D-ribofuranoside.
Claim 12
Dependent Claim
9 words
A compound as in claim 1 which is methyl-5-desoxy-5-(theophyll-7-yl)-2,3-di-O-nicotinoyl-β-D-ribofuranoside.
Claim 13
Dependent Claim
9 words
A compound as in claim 1 which is methyl-5-desoxy-5-(theophyll-7-yl)-2,3-di-O-clofibrinyl-β-D-ribofuranoside.
Claim 14
Dependent Claim
9 words
A compound as in claim 1 which is ethyl-6-desoxy-6-(theophyll-7-yl)-2,3,4-tri-O-nicotinoyl-α-D-glucopyranoside.
Claim 15
Dependent Claim
9 words
A compound as in claim 1 which is methyl-6-desoxy-6-(theophyll-7-yl)-2,3,4-tri-O-benzoyl-α-D-glucopyranoside.
Claim 16
Dependent Claim
27 words
A pharmaceutical composition suitable for the treatment of hyperlipemia comprising a hypolipemically-effective amount of a compound as in claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 17
Dependent Claim
27 words
A method of treating hyperlipemia in a patient suffering therefrom which comprises orally administering to said patient a hypolipemically-effective amount of a compound as in claim 1.
References Cited (Backward Citations)
US2993039A
Cited
US3380996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-23 | 1982-10-23 | 1983-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-23 | 1986-10-23 | 1987-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-23 | 1990-10-23 | 1991-04-24 | $7700.00 | Window Closed / Lapsed |