US4151276A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of suppressing gastric acid secretion by the oral administration of calcitonin
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1975-05-12
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Granted: 1979-04-24
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Expires: 1995-05-12
Abstract
Abstract A method of obtaining suppression of gastric acid secretion in a mammalian host by the oral administration of calcitonin to the host mammal, including man, to obtain the suppression of gastric acid secretion therein. The method is useful in the treatment of mammals having grastric or duodenal ulcers or other conditions which benefit from the suppression of gastric acidity.
Inventors
- 👤 Francine B. Caulin
- 👤 James W. Bastian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 12:47
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/23
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
94 words
A method of suppressing gastric acid secretion in a mammalian host when the suppression of gastric acid secretion in such host is medically desirable comprising administering orally to said host an effective amount of calcitonin selected from the group consisting of calcitonin obtained from salmon, trout, eel, porcine, human or chicken, the synthetic counterparts thereof, and mixtures of any of the foregoing, or their non-toxic pharmaceutically acceptable salts sufficient to suppress gastric acid secretion in said host by local action but insufficient to produce significant systemic effects normally associated with parenteral calcitonin and administration.
Claim 2
Independent Claim
94 words
A method of suppressing gastric acid secretion in a mammalian host when the suppression of gastric acid secretion in such host is medically desirable comprising administering orally to said host an effective amount of calcitonin selected from the group consisting of calcitonin obtained from salmon, trout, eel, porcine, human or chicken, the synthetic counterparts thereof, and mixtures of any of the foregoing, or their non-toxic pharmaceutically acceptable salts sufficient to suppress gastric acid secretion in said host by local action but insufficient to produce significant systemic effects normally associated with parenteral calcitonin and administration.
Claim 3
Dependent Claim
10 words
The method of claim 1 in which calcitonin is synthetic.
Claim 4
Dependent Claim
15 words
The method of claim 1 in which said calcitonin is derived from the ultimobronchial bodies.
Claim 5
Dependent Claim
12 words
The method of claim 1 in which said calcitonin is porcine calcitonin.
Claim 6
Dependent Claim
15 words
The method of claim 3 in which said calcitonin is obtained from salmon ultimobronchial bodies.
Claim 7
Dependent Claim
38 words
The method of claim 1 in which said effective amount comprises from about 0.05 milligrams to about 10 milligrams of calcitonin (based on content of acetic acid salt equivalency) in a regimen of 3-8 hour intervals between administration.
Claim 8
Dependent Claim
18 words
The method of claim 6 in which said effective amount is disposed into a non-toxic pharmaceutical grade carrier.
Claim 9
Dependent Claim
67 words
The method of claim 7 in which said carrier is selected from the group consisting of lactose, starch, sucrose, mannitol, sorbitol, albumin, cellulose powder, talc, stearic acid, gelatin, agar, pectin, acacia, glycols, polyglycols peanut oil, olive oil, sesame oil, corn oil, alcohol, water, albumin solutions, aqueous gelatin and is administered in a dosage form selected from tablets, filled capsules, packets, solution, suspension, emulsion and soft gelatin capsules.
References Cited (Backward Citations)
US3826824A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-23 | 1982-10-23 | 1983-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-23 | 1986-10-23 | 1987-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-23 | 1990-10-23 | 1991-04-24 | $7700.00 | Window Closed / Lapsed |