US4150220A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Semi-synthetic 4"-erythromycin A derivatives
Assignee: Pfizer Inc
•
Filing: 1977-12-01
•
Granted: 1979-04-17
•
Expires: 1997-12-01
Abstract
Abstract A series of 4''-deoxy-4''-amino-erythromycin A antibacterial agents and their preparation from erythromycin A via 4''-deoxy-4''-oxo-erythromycin A intermediates.
Inventors
- 👤 Frank C. Sciavolino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:19
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
65 words
A compound selected from the group consisting of: ##STR44## wherein R 1 is selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms; R 2 is alkanoyl having two to three carbon atoms; Y is selected from the group consisting of N--OH and ##STR45## R 3 is hydrogen; and R 2 and R 3 when taken together are ##STR46##
Claim 2
Dependent Claim
65 words
A compound selected from the group consisting of: ##STR44## wherein R 1 is selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms; R 2 is alkanoyl having two to three carbon atoms; Y is selected from the group consisting of N--OH and ##STR45## R 3 is hydrogen; and R 2 and R 3 when taken together are ##STR46##
Claim 3
Dependent Claim
20 words
A compound of claim 1, Formula I, wherein R 1 is selected from the group consisting of hydrogen and acetyl.
Claim 4
Dependent Claim
6 words
The compound of the formula: ##STR47##
Claim 5
Dependent Claim
6 words
The compound of the formula: ##STR47##
Claim 6
Dependent Claim
6 words
The compound of the formula: ##STR48##
Claim 7
Dependent Claim
6 words
The compound of the formula: ##STR48##
Claim 8
Dependent Claim
6 words
The compound of the formula: ##STR49##
Claim 9
Dependent Claim
6 words
The compound of the formula: ##STR49##
Claim 10
Dependent Claim
6 words
The compound of the formula: ##STR50##
Claim 11
Dependent Claim
6 words
The compound of the formula: ##STR50##
Claim 12
Dependent Claim
20 words
The compound of claim 1, Formula II, wherein R 1 is selected from the group consisting of hydrogen and acetyl.
Claim 13
Dependent Claim
6 words
The compound of the formula: ##STR51##
Claim 14
Dependent Claim
6 words
The compound of the formula: ##STR51##
Claim 15
Dependent Claim
6 words
The compound of the formula: ##STR52##
Claim 16
Dependent Claim
6 words
The compound of the formula: ##STR52##
Claim 17
Dependent Claim
79 words
A 4"-amino epimeric compound selected from the group consisting of: ##STR53## and a pharmaceutically acceptable acid addition salt thereof wherein R 1 and R 4 are each selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms; R 2 is alkanoyl having from two to three carbon atoms; R 3 is hydrogen; R 2 and R 3 when taken together are ##STR54## and R 3 and R 4 when taken together are ##STR55##
Claim 18
Dependent Claim
79 words
A 4"-amino epimeric compound selected from the group consisting of: ##STR53## and a pharmaceutically acceptable acid addition salt thereof wherein R 1 and R 4 are each selected from the group consisting of hydrogen and alkanoyl having from two to three carbon atoms; R 2 is alkanoyl having from two to three carbon atoms; R 3 is hydrogen; R 2 and R 3 when taken together are ##STR54## and R 3 and R 4 when taken together are ##STR55##
Claim 19
Dependent Claim
18 words
A compound of claim 10, Formula III, wherein R 2 and R 3 when taken together are ##STR56##
Claim 20
Dependent Claim
6 words
The compound of the formula: ##STR57##
Claim 21
Dependent Claim
6 words
The compound of the formula: ##STR57##
Claim 22
Dependent Claim
6 words
The compound of the formula: ##STR58##
Claim 23
Dependent Claim
6 words
The compound of the formula: ##STR58##
Claim 24
Dependent Claim
12 words
A compound of claim 10, Formula IV, wherein R 4 is hydrogen.
Claim 25
Dependent Claim
6 words
The compound of the formula: ##STR59##
Claim 26
Dependent Claim
6 words
The compound of the formula: ##STR59##
Claim 27
Dependent Claim
6 words
The compound of the formula: ##STR60##
Claim 28
Dependent Claim
6 words
The compound of the formula: ##STR60##
Claim 29
Dependent Claim
18 words
A compound of claim 10, Formula IV, wherein R 3 and R 4 when taken together are ##STR61##
Claim 30
Dependent Claim
6 words
The compound of the formula: ##STR62##
Claim 31
Dependent Claim
6 words
The compound of the formula: ##STR62##
Claim 32
Dependent Claim
6 words
The compound of the formula: ##STR63##
Claim 33
Dependent Claim
6 words
The compound of the formula: ##STR63##
References Cited (Backward Citations)
US3842069A
Cited
US3884903A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-16 | 1982-10-16 | 1983-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-16 | 1986-10-16 | 1987-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-16 | 1990-10-16 | 1991-04-17 | $7700.00 | Window Closed / Lapsed |