US4148915A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bis(2-phenoxyalkane carboxylic acids) and derivatives thereof and their use as medicaments
Assignee: Laboratoires Albert Rolland SA
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Filing: 1976-11-08
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Granted: 1979-04-10
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Expires: 1996-11-08
Abstract
Abstract Bis (2-phenoxyalkane carboxylic acids) and their esters and salts, as well as a method for their preparation. These compounds are useful for the treatment of hyperlipemia and arteriosclerosis.
Inventors
- 👤 Germaine Thuillier
- 👤 Sylviane S. J. Mignonac
- 👤 Pierre A. R. Bessin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 14:45
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; A; A61; A61P; A61P3/00; A61P3/06; C07C317/00; C07C323/00; C07C59/70
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
81 words
A compound of the formula ##STR11## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is alkyl of 4 to 12 carbon atoms, A is O, S, SO or SO 2 ; and each of X 1 , X 2 , X 3 and X 4 is independently hydrogen, halogen or alkyl of 1 to 3 carbon atoms or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
81 words
A compound of the formula ##STR11## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is alkyl of 4 to 12 carbon atoms, A is O, S, SO or SO 2 ; and each of X 1 , X 2 , X 3 and X 4 is independently hydrogen, halogen or alkyl of 1 to 3 carbon atoms or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
11 words
A compound as claimed in claim 1, wherein R represents hydrogen.
Claim 4
Dependent Claim
17 words
A compound as claimed in claim 1, wherein R represents alkyl of 1 to 5 carbon atoms.
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 1, which is 4,4'-oxy di(ethyl 2-phenoxyoctanoate).
Claim 6
Dependent Claim
20 words
A compound as claimed in claim 1, which is selected from 4,4'-oxy di(2-phenoxy octanoic acid) and its pharmaceutically acceptable salts.
Claim 7
Dependent Claim
23 words
A compound as claimed in claim 1, which is selected from 4,4'-thio di(2-phenoxy octanoic acid) and its esters and its pharmaceutically acceptable salts.
Claim 8
Dependent Claim
12 words
A compound as claimed in claim 1, which is 4,4'-oxy di(ethyl 2-phenoxynonanoate).
Claim 9
Dependent Claim
20 words
A compound as claimed in claim 1, which is selected from 4,4'-oxy di(2-phenoxy undecanoic acid) and its pharmaceutically acceptable salts.
Claim 10
Dependent Claim
130 words
A pharmaceutical composition in dosage unit form for treatment of an animal against hypercholoesterolemia, hypertiglyceridemia, hyperlipemia or arteriosclorosis comprising an amount effective to combat said hypercholoesterolemia, hypertiglyceridemia, hyperlipemia or arterioschlorosis of a compound of the formula ##STR12## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms, or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier therefor.
Claim 11
Dependent Claim
130 words
A pharmaceutical composition in dosage unit form for treatment of an animal against hypercholoesterolemia, hypertiglyceridemia, hyperlipemia or arteriosclorosis comprising an amount effective to combat said hypercholoesterolemia, hypertiglyceridemia, hyperlipemia or arterioschlorosis of a compound of the formula ##STR12## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms, or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier therefor.
Claim 12
Dependent Claim
18 words
The pharmaceutical composition of claim 9 wherein R 2 is an alkyl of 1 to 12 carbon atoms.
Claim 13
Dependent Claim
19 words
The pharmaceutical composition of claim 9 which contains from 1 to 200 mg of active ingredient per dosage unit.
Claim 14
Dependent Claim
12 words
A composition of claim 9 wherein said dosage unit is a tablet.
Claim 15
Dependent Claim
13 words
A composition of claim 9 wherein said dosage unit is a gelatin-coated pill.
Claim 16
Independent Claim
119 words
A method of treating a human against hypercholesterolemia, hypertriglyceridemia, hyperlipemia and arteriosclerosis, wherein there is administered to the human a pharmaceutically acceptable amount of a compound of the formula ##STR13## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkly of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 , and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 17
Independent Claim
119 words
A method of treating a human against hypercholesterolemia, hypertriglyceridemia, hyperlipemia and arteriosclerosis, wherein there is administered to the human a pharmaceutically acceptable amount of a compound of the formula ##STR13## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkly of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 , and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 18
Dependent Claim
16 words
The method of claim 14 wherein R 2 is alkyl of 1 to 12 carbon atoms.
Claim 19
Dependent Claim
19 words
A method as claimed in claim 14, wherein there is administered from 1 to 200 mg of active ingredient.
Claim 20
Independent Claim
119 words
A method of maintaining or decreasing uric acid levels of the body which comprises administering to a patient in need thereof a uricosically effective amount in unit dosage form of a compound of the formula ##STR14## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 , and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms.
Claim 21
Independent Claim
119 words
A method of maintaining or decreasing uric acid levels of the body which comprises administering to a patient in need thereof a uricosically effective amount in unit dosage form of a compound of the formula ##STR14## wherein R is hydrogen or alkyl of 1 to 5 carbon atoms, R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 12 carbon atoms, A is selected from the group consisting of O, S, SO, and SO 2 , and X 1 , x 2 , x 3 , and X 4 are each independently selected from the group consisting of hydrogen, halogen, and alkyl of 1 to 3 carbon atoms.
Claim 22
Dependent Claim
16 words
The method of claim 17 wherein R 2 is alkyl of 1 to 12 carbon atoms.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-09 | 1982-10-09 | 1983-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-09 | 1986-10-09 | 1987-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-09 | 1990-10-09 | 1991-04-10 | $7700.00 | Window Closed / Lapsed |