Basically substituted indole derivatives

Claim 1

A compound of the formula ##STR93## or a physiologically acceptable salt thereof wherein R 1 is piperidino, morpholino, piperazino, or piperazino substituted in the 4-position by (a) alkyl having 1 to 3 carbon atoms (b) β-hydroxyethyl (c) 2-(1,3-dioxolan-2-yl)-ethyl (d) phenyl (e) 3,4-methylene-dioxybenzyl (f) 2-furoyl (g) 3,4,5, -trimethoxybenzoyl (h) alkoxycarbonyl having up to 5 carbon atoms (i) (2-methyl-2-propenyl)-oxycarbonyl, or (j) hydroxyalkyl oxycarbonyl having 2 to 5 carbon atoms; R 2 is hydrogen, dialkylamino having identical alkyl groups each having 1 to 4 carbon atoms, piperazino substituted in the 4-position by (a) alkyl having 1 to 3 carbon atoms (b) β-hydroxyethyl (c) 2-(1,3-dioxolan-2-yl)-ethyl (d) phenyl, or (e) 3,4-methylene-dioxy-benzyl, or R 2 is pyrrolidino, piperidino, 4hydroxy-piperidino, morpholino piperazino, [N-(1-ethinyl-cyclohexyl)]-amino, [N-(4-methylpiperazino)]-amino, [N-(dialkylaminocyclohexyl]-amino wherein each alkyl has 1 to 3 carbon atoms, ##STR94## wherein A 1 is alkylene having 2 or 3 carbon atoms or such alkylene mono-substituted by hydroxy and R 12 and R 13 , taken alone, are each alkyl having 1 to 3 carbon atoms, or, taken together with the nitrogen atom to which they are attached, are morpholino, or R 2 is ##STR95## where A 2 is straight-chain alkylene having 2 or 3 carbon atoms and R 14 and R 15 taken alone, are respectively hydrogen and cyclohexyl, or, taken together with the nitrogen atom to which they are attached, are morpholino; R 3 is hydrogen or methoxy; and R 4 is methyl, phenyl, or methoxyphenyl.