Antibiotic compositions for treating coccidiosis

Claim 1

A veterinary composition for treating coccidiosis comprising in effective amounts a mixture of a compound of formula I ##STR10## in which either (1) R 1 is ethyl or vinyl n is a whole number from 2 to 5 m is 0 or 1 X is --O--, --S-- a group ##STR11## or a group --NR 4 -- in which Y and Z either are both --S-- or one is --S-- and the other is --O-- and R 4 is hydrogen or a group of formula ##STR12## in which R 1 is as defined above, and R 2 and R 3 either (a) are both alkyl, or (b) together with the nitrogen atom form a heterocyclic ring which may contain as a further heteroatom --O--, --S-- or a group --NR 5 -- in which R 5 is lower alkyl or lower hydroxyalkyl, or (c) together with the nitrogen atom form a piperazinyl group in which the second nitrogen atom is substituted by a group R 6 in which R 6 is a lower alkyl group substituted by a lower acyloxy group, or is a lower benzoyloxyalkyl group, or (2) R 1 is as defined above n=2 m=1 R 3 is lower alkyl, lower hydroxyalkyl, lower alkyl substituted by a lower acyloxy group or lower benzoyloxyalkyl, X is --NR 4 -- and R 2 together with R 4 forms an ethylene bridge between both nitrogen atoms, with a polyether antibiotic selected from the group consisting of nigericin, grisorixin, salimonycin, dianemycin, septamycin, antibiotic A 204 A, laidlomycin, lysocellin, lonomycin, lasalocid, A, B, C, D and E and monensin.