US4148785A
Expired / Lapsed
US
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Analgesic polypeptide
Assignee: Wyeth LLC
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Filing: 1978-03-15
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Granted: 1979-04-10
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Expires: 1998-03-15
Abstract
Abstract The polypeptides of the formula: ##STR1## in which R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --OH, --NH 2 or --NHC n H 2n+1 where N is 1,2,3 or 4 Or a pharmaceutically acceptable salt thereof, exert an analgesic effect in warm-blooded animals when peripherally administered.
Inventors
- 👤 Surendra K. Dheer
- 👤 William H. McGregor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:22
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/70; C07K14/702; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
38 words
A polypeptide of the formula: ##STR3## in which R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --NH 2 or --NHC n H 2n+1 where n is 1,2,3, or 4 or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
38 words
A polypeptide of the formula: ##STR3## in which R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --NH 2 or --NHC n H 2n+1 where n is 1,2,3, or 4 or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
25 words
A compound of claim 1 of the formula: R--NH--Tyr--D--Ala--Gly--Phe--D--Val--NH.sub.2 where R is hydrogen, methyl, allyl or cyclopropylmethyl, or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
15 words
The compound of claim 1 which is Tyr--D-Ala--Gly--Phe--D-Val--NH 2 or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
17 words
The compound of claim 1 which is Tyr--D-Ala--Gly--Phe--D-Val--NHC 2 H 5 or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
The compound of claim 1 which is N-methyl--Tyr--D-Ala--Gly--Phe--D-Val--NH 2 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-09 | 1982-10-09 | 1983-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-09 | 1986-10-09 | 1987-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-09 | 1990-10-09 | 1991-04-10 | $7700.00 | Window Closed / Lapsed |