US4146615A
Expired / Lapsed
US
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Chrysanthellum plant extract
Assignee: Meda Pharma SAS
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Filing: 1978-01-19
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Granted: 1979-03-27
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Expires: 1998-01-19
Abstract
Abstract A plant extract rich in triterpenic constituents obtained from chrysanthellum and containing as principle component a triterpenic saponin derivative of echinocystic acid whose glycoside contains rhamnose, glucose and xylose may be prepared by extraction of chrysanthellum plants. The extract has been shown to have pharmacological activity, especially analgesic, anti-inflammatory, capillaroprotective and anti-ulcer activity.
Inventors
- 👤 Francois Fauran
- 👤 Gisele Prat
- 👤 Annie Thibault
- 👤 Claude Andre-Mouries
- 👤 Henri Combier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:59
CPC Classifications
A; A61; A61K; A61K36/00; A61K36/18; A61K36/185; A61K36/28
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
67 words
A method for obtaining an extract having pharmaceutical properties which comprises treating plants of the genus chrysanthellum with a polar organic solvent to obtain an extract, treating the dissolved organic phase to defat and concentrate the pharmaceutical values as a crude precipitate, filtering the crude precipitate, dissolving the precipitate in a low molecular weight organic solvent and reprecipitating the pharmaceutical values with a less polar organic solvent.
Claim 2
Independent Claim
67 words
A method for obtaining an extract having pharmaceutical properties which comprises treating plants of the genus chrysanthellum with a polar organic solvent to obtain an extract, treating the dissolved organic phase to defat and concentrate the pharmaceutical values as a crude precipitate, filtering the crude precipitate, dissolving the precipitate in a low molecular weight organic solvent and reprecipitating the pharmaceutical values with a less polar organic solvent.
Claim 3
Dependent Claim
33 words
The method of claim 1, wherein said polar organic solvent is selected from the group consisting of lower alcohols, lower dialkyl ketones, esters of lower alkyl acids and alcohols, and aqueous mixtures thereof.
Claim 4
Dependent Claim
27 words
The method of claim 1, wherein said polar organic solvent is selected from the group consisting of ethyl acetate, acetone, methanol, ethanol, aqueous methanol, and aqueous ethanol.
Claim 5
Dependent Claim
18 words
The method of claim 3, wherein said defatting comprises concentrating said extract, adding water, and washing with trichloroethylene.
Claim 6
Dependent Claim
13 words
The method of claim 3, wherein the less polar organic solvent is chloroform.
Claim 7
Dependent Claim
12 words
An extract of chrysanthellum plant prepared by the method of claim 5.
Claim 8
Dependent Claim
12 words
An extract of chrysanthellum plant prepared by the method of claim 3.
Claim 9
Dependent Claim
20 words
The method of claim 1, wherein the extract contains as a principal component, a triterpenic saponin derivative of echinocystic acid.
Claim 10
Dependent Claim
12 words
An extract of chrysanthellum plant prepared by the method of claim 8.
Claim 11
Dependent Claim
12 words
An extract of chrysanthellum plant prepared by the method of claim 1.
Claim 12
Independent Claim
65 words
A method for obtaining an extract having pharmaceutical properties from a plant of the genus chrysanthellum which comprises crushing the flower tops of chrysanthellum procumbens, treating the crushed plant with boiling methanol, concentrating the organic extract under vacuum at 60° C., defatting the concentrate with water and trichloroethylene, filtering the precipitate obtained, dissolving the precipitate with methanol and then reprecipitating the pharmaceutical values with chloroform.
Claim 13
Independent Claim
65 words
A method for obtaining an extract having pharmaceutical properties from a plant of the genus chrysanthellum which comprises crushing the flower tops of chrysanthellum procumbens, treating the crushed plant with boiling methanol, concentrating the organic extract under vacuum at 60° C., defatting the concentrate with water and trichloroethylene, filtering the precipitate obtained, dissolving the precipitate with methanol and then reprecipitating the pharmaceutical values with chloroform.
Claim 14
Dependent Claim
12 words
An extract of chrysanthellum procumbens prepared by the method of claim 11.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-26 | 1982-09-25 | 1983-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-26 | 1986-09-25 | 1987-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-26 | 1990-09-25 | 1991-03-27 | $7700.00 | Window Closed / Lapsed |