US4146550A
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Process for the preparation of an aliphatic monoisocyanate
Assignee: Bayer AG
•
Filing: 1977-07-18
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Granted: 1979-03-27
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Expires: 1997-07-18
Abstract
Abstract This invention relates to an improved process for the preparation of an aliphatic monoisocyanate from the corresponding carbamic acid chloride. The carbamic acid chloride is reacted with an active hydrogen compound. The reaction is conducted in the presence of a solvent which is inert under the reaction conditions. Addition compounds are formed with the elimination of hydrogen chloride. The addition compounds are subsequently decomposed by heat into the desired isocyanate with the mixture also containing the active hydrogen compound. The monoisocyanate is subsequently removed by distillation.
Inventors
- 👤 Wolfgang Reichmann
- 👤 Klaus Konig
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:34
CPC Classifications
C; C07; C07C; C07C263/00; C07C263/04
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
196 words
A process for the preparation of monoisocyanates of the formula R--NCO from the corresponding carbamic acid chlorides of the formula R--NH--CO--Cl in which R represents an aliphatic hydrocarbon group having from 1 to 4 carbon atoms, which may be olefinically unsaturated, comprising (A) reacting said carbamic acid chloride with a compound having at least one active hydrogen atom selected from the group consisting of (1) amides of sulfuric acid or amides of organic sulfonic acids, said amides having the grouping SO.sub.2 --NHR.sub.1 in which R 1 represents an aliphatic hydrocarbon group having from 1 to 20 carbon atoms or an aromatic hydrocarbon group having from 6 to 14 carbon atoms, (2) phenols containing at least 1 electrophilic group which increases the acidity of the phenolic hydroxyl group under the reaction conditions of the process, (3) urethanes which are otherwise inert under the reaction conditions, in the presence of a solvent which is inert under the reaction conditions, said reaction resulting in the elimination of hydrogen chloride and the production of addition compounds, (B) decomposing the addition compounds by heat to obtain the desired isocyanate and said active hydrogen compound, and (C) removing the monoisocyanate by distillation.
Claim 2
Dependent Claim
196 words
A process for the preparation of monoisocyanates of the formula R--NCO from the corresponding carbamic acid chlorides of the formula R--NH--CO--Cl in which R represents an aliphatic hydrocarbon group having from 1 to 4 carbon atoms, which may be olefinically unsaturated, comprising (A) reacting said carbamic acid chloride with a compound having at least one active hydrogen atom selected from the group consisting of (1) amides of sulfuric acid or amides of organic sulfonic acids, said amides having the grouping SO.sub.2 --NHR.sub.1 in which R 1 represents an aliphatic hydrocarbon group having from 1 to 20 carbon atoms or an aromatic hydrocarbon group having from 6 to 14 carbon atoms, (2) phenols containing at least 1 electrophilic group which increases the acidity of the phenolic hydroxyl group under the reaction conditions of the process, (3) urethanes which are otherwise inert under the reaction conditions, in the presence of a solvent which is inert under the reaction conditions, said reaction resulting in the elimination of hydrogen chloride and the production of addition compounds, (B) decomposing the addition compounds by heat to obtain the desired isocyanate and said active hydrogen compound, and (C) removing the monoisocyanate by distillation.
Claim 3
Dependent Claim
103 words
A process according to claim 1, characterized in that the compounds which contain at least one active hydrogen atom (a) have a boiling point at least 20° C. above the temperature at which their addition compounds with aliphatic monoisocyanates split back to the original compound; (b) react with carbamic acid chlorides at temperatures within the range of about -20° C. to 130° C. to form isocyanate addition compounds with liberation of hydrogen chloride; and (c) whose addition compounds with aliphatic monoisocyanates decompose into the corresponding monoisocyanate and the active hydrogen compound itself at temperatures in the region of 100° C. to 250° C.
Claim 4
Dependent Claim
16 words
A process according to claim 1 characterized in that the carbamic acid chloride is N-methyl-carbamic acid.
Claim 5
Dependent Claim
45 words
A process according to claim 1, wherein the carbamic acid chloride and the active hydrogen compound are mixed at room temperature and in such proportions that at least one active hydrogen atom of the active hydrogen compound will be available per carbamic acid chloride group.
Claim 6
Dependent Claim
27 words
The process according to claim 1, characterized in that the carbamic acid chlorides are used as about 5 to 50% by weight solutions in their inert solvents.
Claim 7
Dependent Claim
14 words
A process according to claim 5, characterized in that the inert solvent is chlorobenzene.
Claim 8
Dependent Claim
15 words
A process according to claim 5, characterized in that the inert solvent is ethylene chloride.
Claim 9
Dependent Claim
40 words
A process according to claim 1, wherein the reaction between the compound having at least one active hydrogen atom and the carbamic acid chloride is carried out at a temperature within the range of from -20° C. to 100° C.
Claim 10
Dependent Claim
21 words
A process according to claim 8, wherein from 1 to 1.5 active hydrogen atoms are available per carbamic acid chloride group.
Claim 11
Dependent Claim
23 words
A process according to claim 9, wherein said decomposing temperature is within the range of from about 130° C. to about 160° C.
Claim 12
Dependent Claim
31 words
A process according to claim 1, characterized in that the decomposing of the addition compounds is accomplished by heating to a temperature of from about 100° C. to about 250° C.
Claim 13
Dependent Claim
41 words
A process according to claim 11, wherein said addition compound is heated to from about 130° C. to about 160° C. and thereafter temperature is raised to from about 160° C. to about 250° C. in order to complete the decomposition.
Claim 14
Dependent Claim
36 words
A process according to claim 1, characterized in that the amides of sulphuric acid or amides or organic sulphonic acids react with carbamic acid chlorides at temperatures within the range of about 60° to 80° C.
Claim 15
Dependent Claim
115 words
A process according to claim 1, wherein the said amides having the grouping --SO 2 --NHR 1 are selected from the group consisting of SO 2 (NHR 1 ) 2 , R 2 SO 2 NHR 1 , and R 3 (SO 2 NHR 1 ) 2 wherein R 1 and R 2 represent an aliphatic hydrocarbon group having from 1 to 20 carbon atoms or an aromatic hydrocarbon group having from 6 to 14 carbon atoms in which R 1 and R 2 may be the same or different, and R 3 represents an arylene group having from 6 to 15 carbon atoms or an alkylene group having from 3 to 8 carbon atoms.
Claim 16
Dependent Claim
26 words
A process according to claim 14, characterized in that R 1 and/or R 2 represent an aliphatic hydrocarbon group having from 1 to 4 carbon atoms.
Claim 17
Dependent Claim
149 words
A process according to claim 1, wherein said phenols are characterized by the following general formula: ##STR3## wherein R' represents a hydroxyl group or an aliphatic hydrocarbon group having from 1 to 4 carbon atoms which may be olefinically unsaturated or which, together with a second group R', may form a condensed aromatic ring which may be substituted by other groups X and/or by other hydroxyl groups, A represents hydrogen, a group X, an aliphatic hydrocarbon group having from 1 to 3 carbon atoms or a sulphone group, SO 2 , X represents cyano, nitro or halo, n represents 1 or 2, m represents an integer of from 1 to 4, preferably 1 or 2, or, if the compound contains a condensed ring substituted with X or if n represents 2 and A represent SO 2 , m may also represent 0; and y represents 0, 1 or 2.
Claim 18
Dependent Claim
24 words
A process according to claim 1, wherein said phenol is selected from the group consisting of p-chlorophenol; 2,4-dichlorophenol; 2,4,6-trichlorophenol; 4-chloro-2-nitrophenol; 4-chloro-3-methyl phenol; and 2-chloronapthol-1.
Claim 19
Dependent Claim
18 words
A process according to claim 1, wherein X represents chlorine or nitro and n represents the integer 1.
Claim 20
Dependent Claim
27 words
A process according to claim 1, characterized in that the phenols react with carbamic acid chlorides at temperatures within the range of about 40° to 100° C.
Claim 21
Dependent Claim
33 words
A process according to claim 19 in that after 90% of the theoretically possible quantity of hydrogen chloride has split off, the remaining hydrogen chloride is removed by heating to about 130° C.
Claim 22
Dependent Claim
81 words
A process according to claim 1, wherein said urethanes are characterized by the following general formula: ##STR4## wherein R" represents an optionally olefinically unsaturated aliphatic hydrocarbon group having from 1 to 10 carbon atoms or an aromatic hydrocarbon group having from 6 to 10 carbon atoms, B represents an aliphatic hydrocarbon group having from 1 to 10 carbon atoms or a cycloaliphatic hydrocarbon group having from 5 to 10 carbon atoms; and n represents an integer of from 1 to 4.
Claim 23
Dependent Claim
28 words
A process according to claim 21, wherein R" represents an olefinically unsaturated aliphatic hydrocarbon group having from 1 to 4 carbon atoms, a methyl group being particularly preferred.
Claim 24
Dependent Claim
26 words
A process according to claim 1, characterized in that the urethanes react with carbamic acid chlorides at temperatures within the range of 40° to 100° C.
Claim 25
Dependent Claim
34 words
A process according to claim 21, characterized in that after 90% of the theoretically possible quantity of hydrogen chloride has split off, the remaining hydrogen chloride is removed by heating to about 130° C.
Claim 26
Dependent Claim
39 words
The process of claim 1 wherein, when the compounds having at least one active hydrogen atom are amides of sulfuric acid or of organic sulfonic acids, the monoisocyanate is distilled off at temperatures of about 130° to 160° C.
Claim 27
Dependent Claim
38 words
The process of claim 1 wherein, when the compounds which contain at least one active hydrogen atom are phenols containing at least one electrophilic group, the monoisocyanate is distilled off at temperatures of about 160° to 180° C.
Claim 28
Dependent Claim
24 words
The process of claim 21 wherein said urethane groups are prepared from isocyanates selected from the group consisting of N-hexylisocyanate, N-decylisocyanate, phenylisocyanate, and 1-isocyanato-naphthalene.
Claim 29
Dependent Claim
33 words
The process of claim 1 wherein, when urethanes are used as the compounds which contain at least one active hydrogen atom, the monoisocyanate is distilled off at temperatures about 180° to 200° C.
Claim 30
Dependent Claim
61 words
The process of claim 1 wherein said phenols containing at least one electrophilic group which increase the acidity of the phenolic hydroxyl groups is represented by the formula: ##STR5## wherein R' represents hydrogen or a methyl group A represents hydrogen X represents Cl n represents 1 m represents an integer of from 1 to 3 y represents 0, 1 or 2.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-26 | 1982-09-25 | 1983-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-26 | 1986-09-25 | 1987-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-26 | 1990-09-25 | 1991-03-27 | $7700.00 | Window Closed / Lapsed |