US4145426A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-microbial piperidino butan-2-ones
Assignee: Merck and Co Inc
•
Filing: 1977-07-18
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Granted: 1979-03-20
•
Expires: 1997-07-18
Abstract
Abstract Compounds of the structure: ##STR1## where A is either ##STR2## where R 1 to R 4 are various substituents are active as antibacterials and antifungals.
Inventors
- 👤 Nathaniel Grier
- 👤 Richard A. Dybas
- 👤 Bruce E. Witzel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:48
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/10; C07D295/104; C07D295/108; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/40; C07D211/44; C07D211/46
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
78 words
A compound of the formula: ##STR13## wherein R and R 1 are C 1 to C 3 alkyl, hydroxy, C 1 to C 3 hydroxyalkyl, phenyl, carboxy, carboxamido, N-loweralkylcarboxamido said alkyl having up to four carbon atoms, loweralkoxycarbonyl said alkoxy having up to four carbon atoms, 1-pyrrolidinyl and 1-piperidinyl, provided that R and R 1 are substituted at either the 3 or 4 position of the piperidine rings and further provided that said piperidine rings are identically substituted.
Claim 2
Dependent Claim
78 words
A compound of the formula: ##STR13## wherein R and R 1 are C 1 to C 3 alkyl, hydroxy, C 1 to C 3 hydroxyalkyl, phenyl, carboxy, carboxamido, N-loweralkylcarboxamido said alkyl having up to four carbon atoms, loweralkoxycarbonyl said alkoxy having up to four carbon atoms, 1-pyrrolidinyl and 1-piperidinyl, provided that R and R 1 are substituted at either the 3 or 4 position of the piperidine rings and further provided that said piperidine rings are identically substituted.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 which is 3- (4-hydroxypiperidino)methyl!-4-(4-hydroxypiperidino)-butan-2-one.
Claim 4
Dependent Claim
87 words
An antimicrobial composition comprising an antimicrobially effective amount of a compound of the formula: ##STR14## wherein R and R 1 are C 1 to C 3 alkyl, hydroxy, C 1 to C 3 hydroxyalkyl, phenyl, carboxy, carboxamido, N-lower-alkylcarboxamido said alkyl having up to four carbon atoms, lower alkoxycarbonyl said alkoxy having up to four carbon atoms, 1-pyrrolidinyl and 1-piperidinyl, provided that R and R 1 are substituted at the 3 or 4 position of the piperidine rings and further provided that said piperidine rings are identically substituted.
Claim 5
Dependent Claim
87 words
An antimicrobial composition comprising an antimicrobially effective amount of a compound of the formula: ##STR14## wherein R and R 1 are C 1 to C 3 alkyl, hydroxy, C 1 to C 3 hydroxyalkyl, phenyl, carboxy, carboxamido, N-lower-alkylcarboxamido said alkyl having up to four carbon atoms, lower alkoxycarbonyl said alkoxy having up to four carbon atoms, 1-pyrrolidinyl and 1-piperidinyl, provided that R and R 1 are substituted at the 3 or 4 position of the piperidine rings and further provided that said piperidine rings are identically substituted.
Claim 6
Dependent Claim
23 words
A composition according to claim 3 where the carrier is selected from the group consisting of talc, corn starch, alumina and diatomaceous earth.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-19 | 1982-09-18 | 1983-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-19 | 1986-09-18 | 1987-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-19 | 1990-09-18 | 1991-03-20 | $7700.00 | Window Closed / Lapsed |