Skin-care agents containing hydroxyalkyl carboxamides and process

Claim 2

A process for maintaining or restoring hygroscopicity in the skin for the care and protection of the skin of warm-blooded animals comprising topically applying to the skin a safe but effective amount as a moisturizer of a cosmetic agent consisting essentially of from 1 to 20 percent by weight, relative to the total agent, of at least one hydroxyalkyl carboxylic acid amide of the formula ##STR3## wherein R 1 and R 2 are independently of each other a member selected from the group consisting of hydrogen and an alkyl radical having 1 to 4 carbon atoms, R 3 is a member selected from the group consisting of the direct bond and a straight-chain alkylene radical having 1 to 3 carbon atoms which is optionally substituted by one or more groups selected from the group consisting of alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 1 to 4 carbon atoms, and R 4 and R 5 independently of one another are a member selected from the group consisting of hydrogen, an alkyl radical having 1 to 4 carbon atoms and an hydroxyalkyl radical having 2 to 6carbon atoms and 1 to 5 hydroxy groups, and the remainder conventional cosmetic excipients.

Claim 3

The process of claim 1 wherein the hydroxyalkyl carboxylic acid amide or mixture of hydroxyalkyl carboxylic acid amides is present in an amount of from 3 to 10% by weight relative to the total agent.

Claim 4

The process of claim 1 wherein said conventional cosmetic excipients are selected from the group consisting of emulsifiers, fatty substances, vegetable extracts, preservatives, perfumes, thickeners, solvents, surfactants and mixtures thereof, in the conventional quantities.

Claim 5

The process of claim 1 wherein the agent has a slightly acidic pH of about 6.

Claim 6

The process of claim 1 wherein the agent is a soap having a weakly alkaline pH.

Claim 7

The process of claim 1 wherein R 1 and R 2 are each hydrogen and R 3 is the direct bond.

Claim 8

The process of claim 6 wherein the hydroxyalkyl carboxylic acid amide is a member selected from the group consisting of glycolic acid amide, N-(2-hydroxyethyl)-glycolic acid amide, N-(2-hydroxypropyl)-glycolic acid amide, N-(tris-hydroxymethyl-methyl)-glycolic acid amide, and N,N-bis-(2-hydroxyethyl)-glycolic acid amide.

Claim 9

The process of claim 6 wherein R 4 is hydroxyalkyl and R 5 is hydrogen or both R 4 and R 5 are hydroxyalkyl.

Claim 10

The process of claim 1 wherein R 1 is methyl, R 2 is hydrogen and R 3 is the direct bond.

Claim 11

The process of claim 9 wherein the hydroxyalkyl carboxylic acid amide is a member selected from the group consisting of lactic acid amide, N-(2-hydroxyethyl)lactic acid amide, N-(2-hydroxypropyl)lactic acid amide, N-(2-hydroxy-isobutyl)lactic acid amide, N-(1,3-di-hydroxy-2-methyl-2-propyl)lactic acid amide, N-(tris-hydroxy-methyl-methyl)lactic acid amide, N,N-bis-(2-hydroxyethyl)lactic acid amide, and N,N-bis-(2-hydroxypropyl)lactic acid amide.

Claim 12

The process of claim 9 wherein R 4 is hydroxyalkyl and R 5 is hydrogen or both R 4 and R 5 are hydroxyalkyl.

Claim 13

The process of claim 1 wherein the hydroxyalkyl carboxylic acid amide is an α-, β-, or γ- hydroxybutyramide.

Claim 14

The process of claim 12 wherein the hydroxyalkyl carboxylic acid amide is an γ-hydroxybutyramide.

Claim 15

The process of claim 13 wherein the γ-hydroxybutyramide is a member selected from the group consisting of N-(2-hydroxyethyl)-γ-hydroxybutyramide, N-(2-hydroxypropyl)-γ-hydroxybutyramide, N-(2-hydroxy-iso-butyl)-γ-hydroxybutyramide, N-(1,3-dihydroxy-2-methyl-2-propyl)-γ-hydroxybutyramide, N-(tris-hydroxy-methyl-methyl)-γ-hydroxybutyramide, N,N-bis-(2-hydroxyethyl)-γ-hydroxybutyramide, and N,N-bis-(2-hydroxypropyl)-γ-hydroxy-butyramide.

Claim 16

The process of claim 13 wherein R 4 is hydroxyalkyl and R 5 is hydrogen or both R 4 and R 5 are hydroxyalkyl.

Claim 17

The process of claim 1 wherein the hydroxyalkyl carboxylic acid amide is an α- or β-hydroxyisobutyramide.

Claim 18

The process of claim 16 wherein the hydroxyalkyl carboxylic acid amide is an α-hydroxyisobutyramide.

Claim 19

The process of claim 17 wherein the α-hydroxyisobutyramide is a member selected from the group consisting of N-(2-hydroxyethyl)-α-hydroxyisobutyramide, N-(2-hydroxypropyl)-α-hydroxyisobutyramide and N-(2-hydroxyisobutyl)-α-hydroxyisobutyramide.

Claim 20

The process of claim 17 wherein R 4 is hydroxyalkyl and R 5 is hydrogen or both R 4 and R 5 are hydroxyalkyl.

Claim 21

The process of claim 1 wherein the hydroxyalkyl carboxylic acid amide is an hydroxyalkyl propionamide.

Claim 22

The process of claim 20 wherein the hydroxyalkyl propionamide is a member selected from the group consisting of α,α-bis-hydroxymethyl-propionamide and N-(2-hydroxyethyl)-α,α-bis-hydroxymethylpropionamide.

Claim 23

The process of claim 20 wherein R 4 is hydroxyalkyl and R 5 is hydrogen or both R 4 and R 5 are hydroxyalkyl.

Claim 24

A process for maintaining or restoring hygroscopicity in the skin for the care and protection of the skin of warm-blooded animals comprising topically applying to the skin a safe but effective amount as a moisturizer of a cosmetic agent consisting essentially of an emulsion adjusted to a pH between 5 and 7 containing an emulsifier, from 1 to 20 percent by weight, relative to the total agent, of at least one hydroxyalkyl carboxylic acid amide of the formula ##STR4## wherein R 1 and R 2 are independently of each other a member selected from the group consisting of hydrogen and an alkyl radical having 1 to 4 carbon atoms, R 3 is a member selected from the group consisting of the direct bond and a straight-chain alkylene radical having 1 to 3 carbon atoms which is optionally substituted by one or more groups selected from the group consisting of alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 1 to 4 carbon atoms, and R 4 and R 5 independently of one another are a member selected from the group consisting of hydrogen, an alkyl radical having 1 to 4 carbon atoms and an hydroxyalkyl radical having 2 to 6 carbon atoms and 1 to 5 hydroxy groups, and the remainder conventional cosmetic excipients, said emulsion being selected from the group consisting of oil-in-water emulsions and water-in-oil emulsions.

Claim 25

A process for maintaining or restoring hygroscopicity in the skin for the care and protection of the skin of warm-blooded animals comprising topically applying to the skin a safe but effective amount as a moisturizer of a cosmetic agent consisting essentially of an emulsion adjusted to a pH between 5 and 7 containing an emulsifier, from 1 to 20 percent by weight, relative to the total agent, of at least one hydroxyalkyl carboxylic acid amide of the formula ##STR4## wherein R 1 and R 2 are independently of each other a member selected from the group consisting of hydrogen and an alkyl radical having 1 to 4 carbon atoms, R 3 is a member selected from the group consisting of the direct bond and a straight-chain alkylene radical having 1 to 3 carbon atoms which is optionally substituted by one or more groups selected from the group consisting of alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 1 to 4 carbon atoms, and R 4 and R 5 independently of one another are a member selected from the group consisting of hydrogen, an alkyl radical having 1 to 4 carbon atoms and an hydroxyalkyl radical having 2 to 6 carbon atoms and 1 to 5 hydroxy groups, and the remainder conventional cosmetic excipients, said emulsion being selected from the group consisting of oil-in-water emulsions and water-in-oil emulsions.

Claim 26

A process for maintaining or restoring hygroscopicity in the skin for the care and protection of the skin of warm-blooded animals comprising topically applying to the skin a safe but effective amount as a moisturizer of a cosmetic agent consisting essentially of a water and lower alcohol solution adjusted to a pH between 5 and 7 containing from 1 to 20 percent by weight, relative to the total agent, of at least one hydroxyalkyl carboxylic acid amide of the formula ##STR5## wherein R 1 and R 2 are independently of each other a member selected from the group consisting of hydrogen and an alkyl radical having 1 to 4 carbon atoms, R 3 is a member selected from the group consisting of the direct bond and a straight-chain alkylene radical having 1 to 3 carbon atoms which is optionally substituted by one or more groups selected from the group consisting of alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 1 to 4 carbon atoms, and R 4 and R 5 independently of one another are a member selected from the group consisting of hydrogen, an alkyl radical having 1 to 4 carbon atoms and an hydroxyalkyl radical having 2 to 6 carbon atoms and 1 to 5 hydroxy groups, and the remainder conventional cosmetic excipients.

Claim 27

A process for maintaining or restoring hygroscopicity in the skin for the care and protection of the skin of warm-blooded animals comprising topically applying to the skin a safe but effective amount as a moisturizer of a cosmetic agent consisting essentially of a water and lower alcohol solution adjusted to a pH between 5 and 7 containing from 1 to 20 percent by weight, relative to the total agent, of at least one hydroxyalkyl carboxylic acid amide of the formula ##STR5## wherein R 1 and R 2 are independently of each other a member selected from the group consisting of hydrogen and an alkyl radical having 1 to 4 carbon atoms, R 3 is a member selected from the group consisting of the direct bond and a straight-chain alkylene radical having 1 to 3 carbon atoms which is optionally substituted by one or more groups selected from the group consisting of alkyl having 1 to 4 carbon atoms and hydroxyalkyl having 1 to 4 carbon atoms, and R 4 and R 5 independently of one another are a member selected from the group consisting of hydrogen, an alkyl radical having 1 to 4 carbon atoms and an hydroxyalkyl radical having 2 to 6 carbon atoms and 1 to 5 hydroxy groups, and the remainder conventional cosmetic excipients.