US4141986A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotics 890A2 and 890A5
Assignee: Merck and Co Inc
•
Filing: 1977-08-05
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Granted: 1979-02-27
•
Expires: 1997-08-05
Abstract
Abstract The antibiotics MSD 890A2 and MSD 890A5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A2 and 890A5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
Inventors
- 👤 Patrick J. Cassidy
- 👤 Robert T. Goegelman
- 👤 Edward O. Stapley
- 👤 Sebastian Hernandez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 19:51
CPC Classifications
C; C07; C07D; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20; A; A61; A61P; A61P31/00; A61P31/04; C12; C12P; C12P17/00; C12P17/18; C12P17/182; C12P17/184; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
66 words
The compound having the structure: ##STR3## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N); and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
66 words
The compound having the structure: ##STR3## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N); and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
75 words
The compound having the structure: ##STR4## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N); and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
75 words
The compound having the structure: ##STR4## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N); and the pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
133 words
The mixture comprising the compound having the structure: ##STR5## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) and the compound having the structure: ##STR6## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N).
Claim 6
Dependent Claim
133 words
The mixture comprising the compound having the structure: ##STR5## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) and the compound having the structure: ##STR6## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N).
Claim 7
Dependent Claim
80 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR7## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) and pharmaceutically acceptable salts thereof and a non-toxic pharmaceutically acceptable carrier therefore.
Claim 8
Dependent Claim
80 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR7## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) and pharmaceutically acceptable salts thereof and a non-toxic pharmaceutically acceptable carrier therefore.
Claim 9
Dependent Claim
77 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR8## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N).
Claim 10
Dependent Claim
77 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR8## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N).
Claim 11
Dependent Claim
152 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR9## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) in combination with the compound having the structure: ##STR10## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N) and pharmaceutically acceptable salts thereof and a non-toxic pharmaceutically acceptable carrier therefore.
Claim 12
Dependent Claim
152 words
A composition comprising an antibacterial effective amount of the compound having the structure: ##STR9## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.33 (d, J = 6, CH 3 --CH); 2.07 (S, CH 3 C═O); 3.15 (m, C--CH 2 --C); 3.69 (m, >CH--C═O); ˜4.3 (>CHN and >CH--OH), 6.09 and 7.12 (doublets, J = 13.5, S--CH═CH--N) in combination with the compound having the structure: ##STR10## wherein said compound has 100 MHz nuclear magnetic resonance signals having chemical shifts in parts per million and multiplicities indicated as: 1.29 (d, J = 6.2, CH 3 --CH); 2.05 (S, CH 3 C═O); 3.09 (d of d C--CH 2 --C); 3.41 (d of d, J = 5.0, 3.0 >CH--C═O); 4.16 (m, >CH--N and >CH--OH); 6.00 and 7.11 (doublets, J = 13.8, S--CH═CH--N) and pharmaceutically acceptable salts thereof and a non-toxic pharmaceutically acceptable carrier therefore.
References Cited (Backward Citations)
BE827332A
Cited
US3950357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-26 | 1982-08-28 | 1983-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-26 | 1986-08-28 | 1987-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-26 | 1990-08-28 | 1991-02-27 | $7700.00 | Window Closed / Lapsed |