US4140786A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for alleviating angiotensin related hypertension
Assignee: ER Squibb and Sons LLC
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Filing: 1978-03-09
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Granted: 1979-02-20
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Expires: 1998-03-09
Abstract
Abstract A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting enzyme inhibitor selected from a group of mercaptoacyl aminoacids.
Inventors
- 👤 Miguel A. Ondetti
- 👤 David W. Cushman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:43
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
72 words
A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R 1 is imidazolyl-lower alkylene or indolyl-lower alkylene R 2 , R 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
Claim 2
Independent Claim
72 words
A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R 1 is imidazolyl-lower alkylene or indolyl-lower alkylene R 2 , R 3 and R 4 each is hydrogen, lower alkyl or phenyl-lower alkylene; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
Claim 3
Dependent Claim
21 words
A method as in claim 1 wherein the compound has the L-configuration with respect to the carbon bearing R 1 .
Claim 4
Dependent Claim
27 words
A method as in claim 1 wherein in the formula the group ##STR14## is derived from an amino acid of the group consisting of histidine and tryptophane.
Claim 5
Dependent Claim
19 words
A method as in claim 1 wherein the dosage is about 10 to 500 mg. per kilogram per day.
Claim 6
Dependent Claim
40 words
A method as in claim 1 wherein the compound in the formula has R 1 as 3-indolylmethyl, R 2 , R 3 , R 4 and R 5 each as hydrogen and n as 1 and has the name N-(3-mercaptopropanoyl)-L-tryptophane.
Claim 7
Dependent Claim
41 words
A method as in claim 1 wherein the compound in the formula has R 1 as 3-indolylmethyl, R 2 , R 4 and R 5 each as hydrogen, R 3 as methyl and n as 1 and has the name N-(3-mercapto-2-methylpropanoyl)-L-tryptophane.
Claim 8
Dependent Claim
37 words
A method as in claim 1 wherein the compound in the formula has R 1 as 4-imidazolylmethyl, R 2 , R 3 and R 5 each as hydrogen and n as 0 and has the name N-2-mercaptoacetyl-L-histidine.
Claim 9
Dependent Claim
36 words
A method as in claim 1 wherein the compound in the formula has R as 3-indolylmethyl, R 2 , R 3 and R 5 each as hydrogen and n as 0 and has the name N-2-mercaptoacetyl-L-tryptophane.
Claim 10
Dependent Claim
37 words
A method as in claim 1 wherein the compound in the formula has R 1 as 4-imidazolylmethyl, R 2 and R 5 as hydrogen, R 3 as methyl and n as 0 and has the name N-2-mercaptopropanoyl-L-histidine.
Claim 11
Dependent Claim
37 words
A method as in claim 1 wherein the compound in the formula has R 1 as 3-indolylmethyl, R 2 and R 5 as hydrogen, R 3 as methyl and n as 0 and has the name N-2-mercaptopropanoyl-L-tryptophane.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |