US4140698A
Expired / Lapsed
US
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1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
Assignee: Syntex USA LLC
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Filing: 1978-05-30
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Granted: 1979-02-20
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Expires: 1998-05-30
Abstract
Abstract 5-Substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids of the formula ##STR1## wherein Y is a moiety selected from the group consisting of ##STR2## in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring, R 1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R 1 substitution being at the ortho, meta or para positions of the aroyl group, and R 2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, are prepared, by hydrolysis, from their corresponding nitriles.
Inventors
- 👤 Albert R. Van Horn
- 👤 Pasquale G. Gallegra
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 17:37
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/33; C07D207/335; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00; C07D207/337; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
104 words
A compound of the formula: ##STR10## wherein Y is a moiety selected from the group consisting of ##STR11## in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring, R 1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R 1 substitution being at the ortho, meta or para positions of the aroyl group, and R 2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms.
Claim 2
Dependent Claim
104 words
A compound of the formula: ##STR10## wherein Y is a moiety selected from the group consisting of ##STR11## in which R is hydrogen, methyl, chloro or bromo, the R substitution being at the 3, 4 or 5 positions of the thiophene ring, R 1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo, the R 1 substitution being at the ortho, meta or para positions of the aroyl group, and R 2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms.
Claim 3
Dependent Claim
7 words
According to claim 1, the compound 5-(2-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitrile.
Claim 4
Dependent Claim
7 words
According to claim 1, the compound 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitrile.
Claim 5
Dependent Claim
7 words
According to claim 1, the compound 5-m-chlorobenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitrile.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |