US4140691A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole
Assignee: John Wyeth and Brother Ltd
•
Filing: 1977-03-08
•
Granted: 1979-02-20
•
Expires: 1997-03-08
Abstract
Abstract The invention provides a process for preparing indole derivatives in which a compound containing an indole ring linked to an acylamido piperidine ring by a carbonyl alkylene group between the nitrogen of the piperidine and the 3-position of the indole is reduced with alkali-metal borohydride in special solvents so that the carbonyl group is reduced to a CH 2 group.
Inventors
- 👤 George O. Weston
- 👤 Susan E. Murfitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:33
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
22 words
A process for preparing 3-[2-(4-benzamidopiperid-1-yl)ethyl] indole, wherein 3-[2-(4-benzamidopiperid-1-yl)acetyl] indole is reduced by an alkali metal borohydride in isopropanol to give 3-[2-(4-benzamidopiperid-1-yl)ethyl] indole.
Claim 2
Dependent Claim
22 words
A process for preparing 3-[2-(4-benzamidopiperid-1-yl)ethyl] indole, wherein 3-[2-(4-benzamidopiperid-1-yl)acetyl] indole is reduced by an alkali metal borohydride in isopropanol to give 3-[2-(4-benzamidopiperid-1-yl)ethyl] indole.
Claim 3
Dependent Claim
14 words
A process as claimed in claim 1 wherein the reducing agent is sodium borohydride.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |