US4140679A
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Antigen-protein complex for blocking allergic reactions
Assignee: Research Corp
•
Filing: 1976-10-12
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Granted: 1979-02-20
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Expires: 1996-10-12
Abstract
Abstract A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D fragment having the antigenic determinant structure: <IMAGE> wherein:
Inventors
- 👤 Arthur Malley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:05
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; A61P; A61P37/00; A61P37/08; C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/26; C07D311/28; C07D311/30; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07; A61K2039/60; A61K2039/6093; A61K2039/62; A61K2039/627; A61K38/00; Y; Y10; Y10S; Y10S424/00; Y10S424/805; Y10S530/00; Y10S530/806; Y10S530/868
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
112 words
A multivalent complex suitable for blocking allergic reactions selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR11## wherein G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR12## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR13## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
Claim 2
Dependent Claim
112 words
A multivalent complex suitable for blocking allergic reactions selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR11## wherein G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR12## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR13## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
Claim 3
Dependent Claim
64 words
A multivalent complex suitable for blocking allergic reactions comprising at least one antigen D fragment bonded to a protein or peptide and having the formula: ##STR14## wherein: G represents gluclose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety.
Claim 4
Dependent Claim
64 words
A multivalent complex suitable for blocking allergic reactions comprising at least one antigen D fragment bonded to a protein or peptide and having the formula: ##STR14## wherein: G represents gluclose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety.
Claim 5
Dependent Claim
31 words
The conjugate of claim 2 wherein said peptide or protein covalently bonded to said fragment is human serum albumin, a d-amino acid copolymer of lysine and glutamic acid or human IgG.
Claim 6
Dependent Claim
23 words
The conjugate of claim 2 wherein T is a threonine containing peptide such that the molecular weight of said fragment is about 5000.
Claim 7
Dependent Claim
22 words
The conjugate of claim 2 wherein said threonine containing peptide is such that the molecular weight of said fragment is about 2500.
Claim 8
Dependent Claim
9 words
The conjugate of claim 2 wherein T represents threonine.
Claim 9
Dependent Claim
21 words
The conjugate of claim 4 wherein said fragment is covalently bonded to a d-amino acid copolymer of lysine and glutamic acid.
Claim 10
Dependent Claim
14 words
The conjugate of claim 4 wherein said fragment is covalently bonded to human IgG.
Claim 11
Dependent Claim
15 words
The conjugate of claim 4 wherein said fragment is covalently bonded to human serum albumin.
Claim 12
Dependent Claim
21 words
The conjugate of claim 5 wherein said fragment is covalently bonded to a d-amino acid copolymer of lysine and glutamic acid.
Claim 13
Dependent Claim
14 words
The conjugate of claim 5 wherein said fragment is covalently bonded to human IgG.
Claim 14
Dependent Claim
15 words
The conjugate of claim 6 wherein said fragment is covalently bonded to human serum albumin.
Claim 15
Dependent Claim
16 words
A multi-valent complex suitable for blocking allergic reactions comprising a quercitin-glutathione complex having the formula: ##STR15##
Claim 16
Dependent Claim
16 words
A multi-valent complex suitable for blocking allergic reactions comprising a quercitin-glutathione complex having the formula: ##STR15##
Claim 17
Dependent Claim
33 words
A multi-valent complex suitable for blocking allergic reactions comprising at least one quercitin-glutathione complex having the formula: ##STR16## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
Claim 18
Dependent Claim
33 words
A multi-valent complex suitable for blocking allergic reactions comprising at least one quercitin-glutathione complex having the formula: ##STR16## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
Claim 19
Dependent Claim
25 words
The conjugate of claim 14 wherein said protein or peptide is human serum albumin, d-amino acid copolymer of lysine and glutamic acid or human IgG.
Claim 20
Dependent Claim
17 words
The conjugate of claim 14 wherein peptide is a d-amino acid copolymer of lysine and glutamic acid.
Claim 21
Dependent Claim
11 words
The conjugate of claim 14 wherein protein is human serum albumin.
Claim 22
Dependent Claim
10 words
The conjugate of claim 14 wherein protein is human IgG.
Claim 23
Dependent Claim
32 words
A method of forming the conjugate of claim 2 comprising activating the glucose moieties therein by reaction with an activating agent and reacting the thus formed intermediate with a peptide or protein.
Claim 24
Dependent Claim
13 words
The method of claim 19 wherein said activating agent is a cyanogen halide.
Claim 25
Dependent Claim
26 words
The method of claim 19 wherein said protein or peptide is human serum albumin, a d-amino acid copolymer of lysine and glutamic acid or human IgG.
Claim 26
Dependent Claim
9 words
The method of claim 21 wherein T represents threonine.
Claim 27
Dependent Claim
23 words
The method of claim 21 wherein T is a threonine containing peptide such that the molecular weight of said fragment is about 5000.
Claim 28
Dependent Claim
23 words
The method of claim 21 wherein T is a threonine containing peptide such that the molecular weight of said fragment is about 2500.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |