US4140652A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons
Assignee: Individual
•
Filing: 1977-01-12
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Granted: 1979-02-20
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Expires: 1997-01-12
Abstract
Abstract A method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons which comprises sorption of the blood-serum albumin on an anion exchange resin, cation exchange resin, activated carbon or a styrene and divinylbenzene copolymer with a specific surface area of at least 20 m 2 /g. Thereafter, the sorbed albumin is subjected to polycondensation at a temperature ranging from 10° to 90° C. The method according to the present invention practically does not change the initial porous structure of the sorbents, thus ensuring sorption of such compounds as bilirubin, uric acid, creatinine, barbituric acid derivatives, potassium and ammonium ions, phenols, indoles, skatoles.
Inventors
- 👤 Vasily V. Korshak
- 👤 Jury A. Leikin
- 👤 Anatoly J. Neronov
- 👤 Ljudmila A. Tikhonova
- 👤 Anatoly V. Ryabov
- 👤 Oleg V. Kabanov
- 👤 Vitaly D. Gorchakov
- 👤 Nikita G. Evseev
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:59
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/28; B01J20/28054; B01J20/28057; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J20/3274; B01J47/00; B01J47/016
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
67 words
A method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons comprising sorption, on a starting sorbent with a specific surface area of at least 20 m 2 /g, selected from the group consisting of ion exchange resins, activated carbon and a copolymer of styrene and divinylbenzene, of blood-serum albumin and subsequent polycondensation thereof on said sorbent at a temperature ranging from 10° to 90° C.
Claim 2
Independent Claim
67 words
A method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons comprising sorption, on a starting sorbent with a specific surface area of at least 20 m 2 /g, selected from the group consisting of ion exchange resins, activated carbon and a copolymer of styrene and divinylbenzene, of blood-serum albumin and subsequent polycondensation thereof on said sorbent at a temperature ranging from 10° to 90° C.
Claim 3
Dependent Claim
33 words
A method as claimed in claim 1, wherein as the starting sorbent use is made of copolymers of styrene and divinylbenzene, with a specific surface area of more than 50 m 2 /g.
Claim 4
Dependent Claim
38 words
A method as claimed in claim 1, wherein polycondensation is carried out in the presence of a cross-linking agent selected from the group consisting of an aldehyde and nitrous acid at a temperature of 10° to 40° C.
Claim 5
Dependent Claim
43 words
A method as claimed in claim 1, wherein the polycondensation with aldehydes is conducted in the presence of activating agents selected from the group consisting of aminoethanol and aminoacids taken in an amount ranging from 1 to 5 g per g of albumin.
Claim 6
Dependent Claim
10 words
Blood-compatible sorbent produced according to the method of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |