US4139620A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Substituted-3-aminoethoxypyrrolidines and use thereof
Assignee: AH Robins Co Inc
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Filing: 1977-12-05
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Granted: 1979-02-13
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Expires: 1997-12-05
Abstract
Abstract 1-Substituted-3-aminoethoxypyrrolidines having the formula ##STR1## WHEREIN R is benzyl, 2-ethoxyphenoxylower-alkyl, 2-propionyloxy-ethyl, 2-methoxy-4-acetylphenoxylower-alkyl, 4-fluorophenoxy lower alkyl, benzoyloxylower-alkyl, 3,4,5-trimethoxybenzoyloxylower-alkyl, 3,4,5-trimethoxybenzoyl, N-(4-methoxyphenyl) carbamoyl, 2-methoxyphenoxylower-alkyl, 3,4,5-trimethoxyphenyl-acetyl, 2-piperidinoethyl or carbamoyl, and Am is dilower-alkylamino, morpholino or piperidino having hypotensive properties are disclosed.
Inventors
- 👤 Robert F. Boswell, Jr.
- 👤 Robert L. Duncan, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:52
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/12; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
44 words
A pharmaceutical composition having hypotensive activity comprising (a) from 5 milligrams to 500 milligrams of a 1-substituted-3-aminoethoxypyrrolidine selected from those having the formula: ##STR5## wherein; R represents benzyl, 2-ethoxyphenoxylower-alkyl, 2-methoxy-4-acetylphenoxylower-alkyl, 4-fluorophenoxylower-alkyl, 2-methoxyphenoxylower-alkyl, or 2-piperidinoethyl, and Am is morpholino, and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
44 words
A pharmaceutical composition having hypotensive activity comprising (a) from 5 milligrams to 500 milligrams of a 1-substituted-3-aminoethoxypyrrolidine selected from those having the formula: ##STR5## wherein; R represents benzyl, 2-ethoxyphenoxylower-alkyl, 2-methoxy-4-acetylphenoxylower-alkyl, 4-fluorophenoxylower-alkyl, 2-methoxyphenoxylower-alkyl, or 2-piperidinoethyl, and Am is morpholino, and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
22 words
A pharmaceutical composition as defined in claim 1 wherein the 1-substituted-3-aminoethoxypyrrolidine is in the form of a pharmaceutically acceptable acid addition salt.
Claim 4
Dependent Claim
13 words
A pharmaceutical composition as defined in claim 1 wherein the compound is 1-[4-(p-fluorophenoxy)butyl]-3-(2-morpholinoethoxy)pyrrolidine.
Claim 5
Dependent Claim
14 words
A pharmaceutical composition as defined in claim 1 wherein the compound is 1-(2-methoxyphenoxypropyl)-3-(2-morpholinoethoxy) pyrrolidine.
Claim 6
Independent Claim
46 words
A method for producing a hypotensive effect in a host comprising administering to said host an effective amount of 1-substituted-3-aminoethoxypyrrolidine having the formula: ##STR6## wherein; R is benzyl, 2-ethoxyphenoxylower-alkyl, 2-methoxy-4-acetylphenoxylower-alkyl, 4-fluorophenoxy lower-alkyl, 2-methoxyphenoxylower-alkyl, or 2-piperidinoethyl, Am is morpholino, and the pharmaceutically acceptable acid addition salts thereof.
Claim 7
Independent Claim
46 words
A method for producing a hypotensive effect in a host comprising administering to said host an effective amount of 1-substituted-3-aminoethoxypyrrolidine having the formula: ##STR6## wherein; R is benzyl, 2-ethoxyphenoxylower-alkyl, 2-methoxy-4-acetylphenoxylower-alkyl, 4-fluorophenoxy lower-alkyl, 2-methoxyphenoxylower-alkyl, or 2-piperidinoethyl, Am is morpholino, and the pharmaceutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
11 words
The method according to claim 5 wherein the 1-substituted-3-aminoethoxypyrrolidine is 1-[4-(p-fluorophenoxy)butyl]-3-(2-morpholinoethoxy)pyrrolidine.
Claim 9
Dependent Claim
11 words
The method according to claim 5 wherein the 1-substituted-3-aminoethoxypyrrolidine is 1-(2-methoxyphenoxypropyl)-3-(2-morpholinoethoxy)pyrrolidine.
Claim 10
Dependent Claim
1 words
1-Benzyl-3-(2-morpholinoethoxy)pyrrolidine.
Claim 11
Dependent Claim
1 words
1-Benzyl-3-(2-morpholinoethoxy)pyrrolidine.
Claim 12
Dependent Claim
2 words
1-Benzyl-3-(2-morpholinoethoxy)pyrrolidine dioxalate.
Claim 13
Dependent Claim
2 words
1-Benzyl-3-(2-morpholinoethoxy)pyrrolidine dioxalate.
References Cited (Backward Citations)
US3984436A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-12 | 1982-08-14 | 1983-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-12 | 1986-08-14 | 1987-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-12 | 1990-08-14 | 1991-02-13 | $7700.00 | Window Closed / Lapsed |