US4138013A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enteric capsules
Assignee: Parke Davis and Co LLC
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Filing: 1977-06-13
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Granted: 1979-02-06
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Expires: 1997-06-13
Abstract
Abstract Pharmaceutical capsules with telescopically engaged body and cap portions, also known as hard shell capsules, having enteric properties. The capsule body and cap portions are formed by dip-molding using a homogeneous film-forming mixture comprising (1) hydroxypropyl methylcellulose and an ammonium salt of cellulose acetate phthalate polymer, or (2) gelatin and an ammonium salt of a copolymer of methacrylic acid and methacrylic acid alkyl ester; optionally with the inclusion of plasticizer and/or coloring agent. The capsules are soluble in or disintegrated by the alkaline intestinal secretions but are substantially insoluble or resistant to solution in the acid secretions of the stomach.
Inventors
- 👤 Yakutaro Okajima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:00
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4816; Y; Y10; Y10S; Y10S220/00; Y10S220/34
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
122 words
A hard-shell pharmaceutical capsule comprising telescopically engaged body and cap portions having enteric properties, being characterized by relative freedom from brittleness and by substantial absence of degradation on exposure to artificial gastric juice for 120 minutes, and the body and cap portions being formed by the dip-moldng technique from a homogeneous film-forming composition comprising a member of the group consisting of (1) hydroxypropyl methylcellulose and an ammonium salt of cellulose acetate phthalate polymer, and (2) gelatin and an ammonium salt of a copolymer of methacrylic acid and methacrylic acid ester, the capsule having the proportion of 5 parts by weight of the ammonium salt, measured as free acid form, to 1 to 5 parts by weight of the gelatin or hydroxypropyl methylcellulose.
Claim 2
Dependent Claim
122 words
A hard-shell pharmaceutical capsule comprising telescopically engaged body and cap portions having enteric properties, being characterized by relative freedom from brittleness and by substantial absence of degradation on exposure to artificial gastric juice for 120 minutes, and the body and cap portions being formed by the dip-moldng technique from a homogeneous film-forming composition comprising a member of the group consisting of (1) hydroxypropyl methylcellulose and an ammonium salt of cellulose acetate phthalate polymer, and (2) gelatin and an ammonium salt of a copolymer of methacrylic acid and methacrylic acid ester, the capsule having the proportion of 5 parts by weight of the ammonium salt, measured as free acid form, to 1 to 5 parts by weight of the gelatin or hydroxypropyl methylcellulose.
Claim 3
Dependent Claim
14 words
A pharmaceutical capsule according to claim 1 and containing up to 5% of glycerine.
Claim 4
Dependent Claim
12 words
A pharmaceutical capsule according to claim 1 and containing a coloring agent.
Claim 5
Dependent Claim
15 words
A pharmaceutical capsule according to claim 1 and containing up to 5% of propylene glycol.
Claim 6
Dependent Claim
24 words
A pharmaceutical capsule according to claim 1 formed from a homogeneous composition comprising hydroxypropyl methylcellulose and an ammonium salt of cellulose acetate phthalate polymer.
Claim 7
Dependent Claim
28 words
A pharmaceutical capsule according to claim 1 formed from a homogeneous composition comprising gelatin and an ammonium salt of a copolymer of methacrylic acid and methacrylic acid ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-05 | 1982-08-07 | 1983-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-05 | 1986-08-07 | 1987-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-05 | 1990-08-07 | 1991-02-06 | $7700.00 | Window Closed / Lapsed |