US4137328A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenyl-alkanolamine, alkylamine and α-aminoalkyl ketone derivatives as heart stimulants
Assignee: Pfizer Inc
•
Filing: 1978-01-27
•
Granted: 1979-01-30
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Expires: 1998-01-27
Abstract
Abstract Novel substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylaminoalkanes and alpha -aminoalkyl phenyl ketones useful as heart stimulants are disclosed.
Inventors
- 👤 David A. Cox
- 👤 Ian T. Barnish
- 👤 Anthony G. Evans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:42
CPC Classifications
C; C07; C07C; C07C275/00; C07C275/28; C07C275/32; C07C275/34
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
179 words
A method of stimulating the heart in an animal subject suffering from congestive heart failure, which comprises administering to said subject an effective amount of a compound selected from the group consisting of substituted 1-phenyl-2-aminoalkanol, 1-phenyl-2-alkylaminoalkane and α-aminoalkyl phenyl ketone bases of the formula: ##STR22## and the pharmaceutically acceptable acid addition salts thereof, wherein R and R 1 are each hydrogen or hydroxy with the proviso that at least one is hydroxy; R 2 is hydrogen, alkyl of from 1 to 4 carbon atoms or alkoxy of from 1 to 4 carbon atoms; R 3 is formamido, acetamido, propionamido and carbamoyl, any one of which may be separated from the phenyl ring by a methylene or ethylene group; R 4 , R 5 and R 6 are each hydrogen or alkyl of from 1 to 4 carbon atoms; X is oxygen, sulfur, imino or a direct link; Y is hydrogen and hydroxy, two hydrogens or oxygen; n is 1 to 3 when X is other than a direct link and 0 to 4 when X is a direct link.
Claim 2
Independent Claim
179 words
A method of stimulating the heart in an animal subject suffering from congestive heart failure, which comprises administering to said subject an effective amount of a compound selected from the group consisting of substituted 1-phenyl-2-aminoalkanol, 1-phenyl-2-alkylaminoalkane and α-aminoalkyl phenyl ketone bases of the formula: ##STR22## and the pharmaceutically acceptable acid addition salts thereof, wherein R and R 1 are each hydrogen or hydroxy with the proviso that at least one is hydroxy; R 2 is hydrogen, alkyl of from 1 to 4 carbon atoms or alkoxy of from 1 to 4 carbon atoms; R 3 is formamido, acetamido, propionamido and carbamoyl, any one of which may be separated from the phenyl ring by a methylene or ethylene group; R 4 , R 5 and R 6 are each hydrogen or alkyl of from 1 to 4 carbon atoms; X is oxygen, sulfur, imino or a direct link; Y is hydrogen and hydroxy, two hydrogens or oxygen; n is 1 to 3 when X is other than a direct link and 0 to 4 when X is a direct link.
Claim 3
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is DL-2-[2-(4-formamidophenoxy)ethylamino]-1-(4-hydroxyphenyl)ethanol.
Claim 4
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is DL-2-[2-(4-acetamidophenoxy)ethylamino]-1-(4-hydroxyphenyl)ethanol.
Claim 5
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is DL-2-[2-(4-carbamoylphenoxy)ethylamino]-1-(4-hydroxyphenyl)ethanol.
Claim 6
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is DL-2-[2-(4-carbamoylmethylphenoxy)ethylamino]-1-(4-hydroxyphenyl)ethanol.
References Cited (Backward Citations)
US4086272A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |