US4133890A
Expired / Lapsed
US
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Hypolipidemic compositions and method employing derivatives of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid
Assignee: Dow Chemical Co
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Filing: 1977-07-25
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Granted: 1979-01-09
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Expires: 1997-07-25
Abstract
Abstract This invention relates to compositions of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in mammals using the compounds and compositions.
Inventors
- 👤 Eugene R. Wagner
- 👤 Alfred A. Renzi
- 👤 Bobbie J. Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:30
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/58; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/357; A61K31/36
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
61 words
A method for lowering serum lipid levels in a mammal which comprises administering internally to the mammal a hypolipidemically effective amount of a compound having the formula ##STR3## wherein R 1 represents hydrogen or methyl and R 2 represents hydroxy, lower alkoxy, amino, N,N-diloweralkylaminoloweralkoxy, or carboxyloweralkylamino; and when R 2 is hydroxy, the symmetrical anhydrides or pharmaceutically-acceptable salts of said compound.
Claim 2
Independent Claim
61 words
A method for lowering serum lipid levels in a mammal which comprises administering internally to the mammal a hypolipidemically effective amount of a compound having the formula ##STR3## wherein R 1 represents hydrogen or methyl and R 2 represents hydroxy, lower alkoxy, amino, N,N-diloweralkylaminoloweralkoxy, or carboxyloweralkylamino; and when R 2 is hydroxy, the symmetrical anhydrides or pharmaceutically-acceptable salts of said compound.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the compound is 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein R 2 is a lower alkoxy of from one to about three carbon atoms.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein the compound is a pharmaceutically-acceptable salt of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid.
Claim 6
Dependent Claim
10 words
The method of claim 1 wherein R 2 is N,N-diloweralkylaminoloweralkoxy.
Claim 7
Dependent Claim
10 words
The method of claim 1 wherein R 2 is carboxyloweralkylamino.
Claim 8
Dependent Claim
10 words
The method of claim 1 wherein the animal is hyperlipidemic.
Claim 9
Dependent Claim
10 words
The method of claim 7 wherein the animal is hypercholesterolemic.
Claim 10
Dependent Claim
10 words
The method of claim 7 wherein the animal is hypertriglyceridemic.
Claim 11
Dependent Claim
53 words
A hypolipidemic composition comprising, a suitable pharmaceutical carrier and a hypolipidemically effective amount of a compound having the formula ##STR4## wherein R 1 represents hydrogen or methyl and R 2 represents hydroxy, lower alkoxy, amino, N,N-diloweralkylaminoloweralkoxy, or carboxyloweralkylamino; and when R 2 is hydroxy, the symmetrical anhydrides or pharmaceutically-acceptable salts of said compound.
Claim 12
Dependent Claim
53 words
A hypolipidemic composition comprising, a suitable pharmaceutical carrier and a hypolipidemically effective amount of a compound having the formula ##STR4## wherein R 1 represents hydrogen or methyl and R 2 represents hydroxy, lower alkoxy, amino, N,N-diloweralkylaminoloweralkoxy, or carboxyloweralkylamino; and when R 2 is hydroxy, the symmetrical anhydrides or pharmaceutically-acceptable salts of said compound.
Claim 13
Dependent Claim
11 words
The composition of claim 10 wherein the compound is 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid.
Claim 14
Dependent Claim
20 words
The composition of claim 10 wherein R 2 is a lower alkoxy of from about 1 to 3 carbon atoms.
Claim 15
Dependent Claim
15 words
The composition of claim 10 wherein the compound is a pharmaceutically-acceptable salt of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid.
Claim 16
Dependent Claim
10 words
The composition of claim 10 wherein R 2 is N,N-diloweralkylaminoloweralkoxy.
Claim 17
Dependent Claim
10 words
The composition of claim 10 wherein R 2 is carboxyloweralkylamino.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-08 | 1982-07-10 | 1983-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-08 | 1986-07-10 | 1987-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-08 | 1990-07-10 | 1991-01-09 | $7700.00 | Window Closed / Lapsed |