US4132776A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Delivery of immunologically active components of transfer factor
Assignee: JETER WAYBURN S
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Filing: 1978-02-15
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Granted: 1979-01-02
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Expires: 1998-02-15
Abstract
Abstract Dialyzable nucleopeptide leucocytic extracts (transfer factors), isolated from animals sensitized to selected antigenic substances, are subjected to treatment in a digestive environment and immunologically active components thereof are administered to the circulatory system of a recipient animal, preferably through digestive tract tissue, to enhance the immunological competence of the recipient.
Inventors
- 👤 Wayburn S. Jeter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:03
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/15; A61K35/17; A61K39/00; A61K39/02; A61K39/04; A61K2039/555; A61K2039/55588
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
138 words
In the method for enhancing the immunological competance of an animal's response to a selected antigenic substance wherein transfer factor isolated from leucocytes of a donor animal sensitized to said antigenic substance is provided to the circulatory system of an animal in need of such enhancement, an improvement in delivery of an immunologically active component of said transfer factor to the circulatory system of an animal comprising: administering to the alimentary canal of a recipient animal from about 1 × 10 8 to about 1 × 10 10 lymphocyte equivalents of said transfer factor in a pharmaceutically acceptable carrier, whereby said transfer factor is subject to a digestive environment in the recipient animal's digestive tract and the immunologically active component of said transfer factor is absorbed through the digestive tract tissue and transported to the animal's circulatory system.
Claim 2
Dependent Claim
138 words
In the method for enhancing the immunological competance of an animal's response to a selected antigenic substance wherein transfer factor isolated from leucocytes of a donor animal sensitized to said antigenic substance is provided to the circulatory system of an animal in need of such enhancement, an improvement in delivery of an immunologically active component of said transfer factor to the circulatory system of an animal comprising: administering to the alimentary canal of a recipient animal from about 1 × 10 8 to about 1 × 10 10 lymphocyte equivalents of said transfer factor in a pharmaceutically acceptable carrier, whereby said transfer factor is subject to a digestive environment in the recipient animal's digestive tract and the immunologically active component of said transfer factor is absorbed through the digestive tract tissue and transported to the animal's circulatory system.
Claim 3
Dependent Claim
16 words
The improvement of claim 1 wherein the donor and recipient animals are of the same species.
Claim 4
Dependent Claim
20 words
The improvement of claim 1 wherein the quantity of transfer factor administered is about 1 × 10 9 lymphocyte equivalents.
Claim 5
Dependent Claim
14 words
The improvement of claim 1 wherein said pharmaceutically acceptable carrier is a saline solution.
Claim 6
Dependent Claim
19 words
The improvement of claim 1 wherein the transfer factor administered is isolated from the blood of said donor animal.
Claim 7
Dependent Claim
20 words
The improvement of claim 1 wherein the transfer factor administered is isolated from the spleen tissue of the donor animal.
Claim 8
Dependent Claim
20 words
The improvement of claim 1 wherein the transfer factor is isolated from the lymph node tissue of the donor animal.
Claim 9
Dependent Claim
20 words
The improvement of claim 1 wherein the transfer factor administered is isolated from an intraperitoneal exudate of the donor animal.
Claim 10
Dependent Claim
79 words
An improved method for delivery of an immunologically active component of a transfer factor which is isolated as a leucocytic extract of a donor animal sensitized to a selected antigenic substance, said method comprising subjecting said extract to treatment in a digestive environment to substantially free the active component therein from extraneous polypeptide or polynucleotide materials normally associated with said active component in said extract, and administering the resultant treated extract to the circulatory system of a recipient animal.
Claim 11
Dependent Claim
79 words
An improved method for delivery of an immunologically active component of a transfer factor which is isolated as a leucocytic extract of a donor animal sensitized to a selected antigenic substance, said method comprising subjecting said extract to treatment in a digestive environment to substantially free the active component therein from extraneous polypeptide or polynucleotide materials normally associated with said active component in said extract, and administering the resultant treated extract to the circulatory system of a recipient animal.
Claim 12
Dependent Claim
25 words
The method of claim 9 wherein said treatment and administration steps jointly comprise introduction of the extract into the alimentary canal of the recipient animal.
Claim 13
Dependent Claim
30 words
The method of claim 9 wherein said treatment step is carried out in vitro and the resultant treated extract is reclaimed from said digestive environment prior to said administration step.
Claim 14
Dependent Claim
16 words
The method of claim 11 wherein said administration step includes parenteral administration of said reclaimed extract.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-01 | 1982-07-03 | 1983-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-01 | 1986-07-03 | 1987-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-01 | 1990-07-03 | 1991-01-02 | $7700.00 | Window Closed / Lapsed |