US4129730A
Expired / Lapsed
US
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7α-Methoxy-cephalosporins
Assignee: Toyama Chemical Co Ltd
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Filing: 1977-01-13
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Granted: 1978-12-12
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Expires: 1997-01-13
Abstract
Abstract Novel 7 alpha -methoxy-cephalosporins and non-toxic salts thereof, which contain a di-oxo-piperazinylcarbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds.
Inventors
- 👤 Isamu Saikawa
- 👤 Shuntaro Takano
- 👤 Hiroyuki Imaizumi
- 👤 Isamu Takakura
- 👤 Hirokazu Ochiai
- 👤 Takashi Yasuda
- 👤 Hideo Taki
- 👤 Masaru Tai
- 👤 Yutaka Kodama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:04
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/57; A; A61; A61P; A61P31/00; A61P31/04; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
132 words
A 7 α-methoxy-cephalosporin represented by the formula: ##STR34## wherein R.sup. 1 is a hydrogen atom, a protective group, or a pharmaceutically acceptable salt-forming cation; R 2 is an acetoxy, propionyloxy, butyryloxy, benzoyloxy, naphthoyloxy, cyclopentanecarbonyloxy, cyclohexanecarbonyloxy, furoyloxy, or thenoyloxy group which is unsubstituted or substituted by a halogen atom, an alkyl group having 1 to 13 carbon atoms, or an alkyloxy or a hydroxyalkyl group each having 1 to 5 carbon atoms; R 3 and R 4 represent independently a hydrogen atom or a lower alkyl group; A is an alkyl group having 1 to 13 carbon atoms which is unsubstituted or substituted by a halogen atom, a hydroxyl group, or an alkyloxy or alkythio group each having 1 to 5 carbon atoms, and X is a hydrogen atom or a hydroxyl group.
Claim 2
Dependent Claim
132 words
A 7 α-methoxy-cephalosporin represented by the formula: ##STR34## wherein R.sup. 1 is a hydrogen atom, a protective group, or a pharmaceutically acceptable salt-forming cation; R 2 is an acetoxy, propionyloxy, butyryloxy, benzoyloxy, naphthoyloxy, cyclopentanecarbonyloxy, cyclohexanecarbonyloxy, furoyloxy, or thenoyloxy group which is unsubstituted or substituted by a halogen atom, an alkyl group having 1 to 13 carbon atoms, or an alkyloxy or a hydroxyalkyl group each having 1 to 5 carbon atoms; R 3 and R 4 represent independently a hydrogen atom or a lower alkyl group; A is an alkyl group having 1 to 13 carbon atoms which is unsubstituted or substituted by a halogen atom, a hydroxyl group, or an alkyloxy or alkythio group each having 1 to 5 carbon atoms, and X is a hydrogen atom or a hydroxyl group.
Claim 3
Dependent Claim
16 words
The α-methoxy-cephalosporin according to claim 1, wherein R 2 is an acetoxy, propionyloxy or butyryloxy group.
Claim 4
Dependent Claim
37 words
The 7α-methoxy-cephalosporin according to claim 2, wherein R 2 is an acetoxy group; R 3 is a hydrogen atom; R 4 is a hydrogen atom or a lower alkyl group; and A is a lower alkyl group.
Claim 5
Dependent Claim
21 words
The 7α-methoxy-cephalosporin according to claim 3, wherein R 4 is a hydrogen atom; and A is a methyl or ethyl group.
Claim 6
Dependent Claim
8 words
7β-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]-7α-methoxy-3-acetoxy-methyl-Δ 3 -cephem-4-carboxylic acid or its non-toxic salt.
Claim 7
Dependent Claim
8 words
7β-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]-7α-methoxy-3-acetoxy-methyl-Δ 3 -cephem-4-carboxylic acid or its non-toxic salt.
Claim 8
Dependent Claim
8 words
7β-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-p-hydroxyphenylacetamido]-7α-methoxy-3-acetoxymethyl-Δ 3 -cephem-4-carboxylic acid or its non-toxic salt.
Claim 9
Dependent Claim
8 words
7β-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)-p-hydroxyphenylacetamido]-7α-methoxy-3-acetoxymethyl-Δ 3 -cephem-4-carboxylic acid or its non-toxic salt.
References Cited (Backward Citations)
US3956292A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-11 | 1982-06-12 | 1982-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-11 | 1986-06-12 | 1986-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-11 | 1990-06-12 | 1990-12-12 | $7700.00 | Window Closed / Lapsed |