US4128552A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenylthio-1,2,3,6-tetrahydropyridines and related sulfoxides and sulfones
Assignee: Warner Lambert Co LLC
•
Filing: 1977-09-26
•
Granted: 1978-12-05
•
Expires: 1997-09-26
Abstract
Abstract Diphenylbutyltetrahydropyridines of the following formula: ##STR1## are disclosed, in which X is hydrogen, halogen such as fluorine, chlorine or bromine, trifluoromethyl, alkoxy, nitro, amino, lower alkyl of 1 to 6 carbon atoms, aryl or substituted aryl and n is 0, 1 or 2. These compounds are useful as antipsychotics.
Inventors
- 👤 Lawrence D. Wise
- 👤 Patrick F. Flynn
- 👤 Glenn C. Morrison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:25
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/68; C07D211/72
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
42 words
A compound of the formula: ##STR18## in which X is hydrogen, halogen, trifluoromethyl, lower alkoxy, aryl of 6 to 10 carbon atoms, lower alkyl, nitro or amino n is 0, 1 or 2 and the corresponding pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
42 words
A compound of the formula: ##STR18## in which X is hydrogen, halogen, trifluoromethyl, lower alkoxy, aryl of 6 to 10 carbon atoms, lower alkyl, nitro or amino n is 0, 1 or 2 and the corresponding pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
19 words
A compound according to claim 1 in which X is hydrogen and n is 2 and its hydrochloride salt.
Claim 4
Dependent Claim
15 words
A compound according to claim 1 in which X is parafluoro and n is 2.
Claim 5
Dependent Claim
14 words
A compound according to claim 1 wherein X is parachloro and n is 2.
Claim 6
Dependent Claim
15 words
A compound according to claim 1 in which X is parabromo and n is 2.
Claim 7
Dependent Claim
15 words
A compound according to claim 1 in which X is paranitro and n is 2.
Claim 8
Dependent Claim
15 words
A compound according to claim 1 in which X is paramethyl and n is 2.
Claim 9
Dependent Claim
15 words
A compound according to claim 1 in which X is metatrifluoromethyl and n is 2.
Claim 10
Dependent Claim
15 words
A compound according to claim 1 in which X is hydrogen and n is 1.
Claim 11
Dependent Claim
15 words
A compound according to claim 1 in which X is parafluoro and n is 1.
Claim 12
Dependent Claim
15 words
A compound according to claim 1 in which X is bromo and n is 1.
Claim 13
Dependent Claim
15 words
A compound according to claim 1 in which X is nitro and n is 1.
Claim 14
Dependent Claim
15 words
A compound according to claim 1 in which X is paramethoxy and n is 1.
Claim 15
Dependent Claim
15 words
A compound according to claim 1 in which X is methyl and n is 1.
Claim 16
Dependent Claim
15 words
A compound according to claim 1 in which X is metatrifluoromethyl and n is 1.
Claim 17
Dependent Claim
16 words
A compound according to claim 1 in which X is ortho, ortho-dichloro and n is 1.
Claim 18
Dependent Claim
15 words
A compound according to claim 1 in which X is hydrogen and n is 0.
Claim 19
Dependent Claim
15 words
A compound according to claim 1 in which X is parafluoro and n is 0.
Claim 20
Dependent Claim
15 words
A compound according to claim 1 in which X is parachloro and n is 0.
Claim 21
Dependent Claim
15 words
A compound according to claim 1 in which X is parabromo and n is 0.
Claim 22
Dependent Claim
15 words
A compound according to claim 1 in which X is paranitro and n is 0.
Claim 23
Dependent Claim
15 words
A compound according to claim 1 in which X is paramethoxy and n is 0.
Claim 24
Dependent Claim
15 words
A compound according to claim 1 in which X is paramethyl and n is 0.
Claim 25
Dependent Claim
15 words
A compound according to claim 1 in which X is metatrifluoromethyl and n is 0.
Claim 26
Dependent Claim
16 words
A compound according to claim 1 in which X is ortho, ortho-dichloro and n is 0.
Claim 27
Dependent Claim
28 words
A compound of the formula II: ##STR19## in which X is hydrogen, halogen, trifluoromethyl, lower alkoxy, aryl of 6 to 10 carbon atoms, lower alkyl, nitro, or amino.
Claim 28
Dependent Claim
28 words
A compound of the formula II: ##STR19## in which X is hydrogen, halogen, trifluoromethyl, lower alkoxy, aryl of 6 to 10 carbon atoms, lower alkyl, nitro, or amino.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-04 | 1982-06-05 | 1982-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-04 | 1986-06-05 | 1986-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-04 | 1990-06-05 | 1990-12-05 | $7700.00 | Window Closed / Lapsed |