US4127729A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amino acid derivatives
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-02-21
•
Granted: 1978-11-28
•
Expires: 1998-02-21
Abstract
Abstract New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:11
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P9/00; A61P9/12; C07C; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/46; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
85 words
A compound of the formula ##STR10## and salts thereof, wherein R is hydroxy or lower alkoxy; R 1 is hydrogen, lower alkanoyl, benzoyl or ##STR11## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylthio-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene; X is carboxy, lower alkoxycarbonyl, carbamoyl, N-substituted carbamoyl wherein the N-substituent is lower alkyl or phenyl-lower alkylene, or cyano; m is 0 or 1; and n is 0, 1,2,3 or 4.
Claim 2
Dependent Claim
85 words
A compound of the formula ##STR10## and salts thereof, wherein R is hydroxy or lower alkoxy; R 1 is hydrogen, lower alkanoyl, benzoyl or ##STR11## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylthio-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene; X is carboxy, lower alkoxycarbonyl, carbamoyl, N-substituted carbamoyl wherein the N-substituent is lower alkyl or phenyl-lower alkylene, or cyano; m is 0 or 1; and n is 0, 1,2,3 or 4.
Claim 3
Dependent Claim
42 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen or lower alkanoyl; X is lower alkoxycarbonyl or carbamoyl; A is hydrogen; B is lower alkyl or amino-lower alkylene; m is 1 and n is 1 or 2.
Claim 4
Dependent Claim
27 words
A compound as in claim 1 wherein ##STR12## is the radical of glycine, alanine, leucine, threonine, lysine, arginine, glutamine, methionine, serine, cysteine, valine, asparagine or glutamic acid.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 1 is ##STR13##
Claim 6
Dependent Claim
11 words
A compound as in claim 1 wherein X is lower alkoxycarbonyl.
Claim 7
Dependent Claim
10 words
A compound as in claim 1 wherein X is carbamoyl.
Claim 8
Dependent Claim
30 words
A compound as in claim 1 wherein R is hydroxy; A and R 1 each is hydrogen; B is carboxymethylene; X is methoxycarbonyl; and m and n each is 1.
Claim 9
Dependent Claim
30 words
A compound as in claim 1 wherein R is hydroxy; A and R 1 each is hydrogen; B is methyl; X is carbamoyl; and m and n each is 1.
Claim 10
Dependent Claim
30 words
A compound as in claim 1 wherein R is hydroxy; A and R 1 each is hydrogen; B is 4-aminobutyl; X is methoxycarbonyl; and m and n each is 1.
Claim 11
Dependent Claim
30 words
A compound as in claim 1 wherein R is hydroxy; A and R 1 each is hydrogen; B is methyl; X is methoxycarbonyl; and m and n each is 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-27 | 1982-05-29 | 1982-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-27 | 1986-05-29 | 1986-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-27 | 1990-05-29 | 1990-11-28 | $7700.00 | Window Closed / Lapsed |