US4126693A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Retinoic acid derivatives in the treatment of acne
Assignee: Johnson and Johnson
•
Filing: 1977-08-05
•
Granted: 1978-11-21
•
Expires: 1997-08-05
Abstract
Abstract Esters and amides of all-trans-retinoic acid are disclosed which are useful for the treatment of acne.
Inventors
- 👤 Robert J. Gander
- 👤 John A. Gurney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:49
CPC Classifications
C; C07; C07C; C07C403/00; C07C403/20; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/58; C07B; C07B2200/00; C07B2200/09; C07C2601/00; C07C2601/12; C07C2601/16
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
1 words
N-(3,4-Methylenedioxyphenylmethyl)-all-trans-retinamide.
Claim 2
Dependent Claim
1 words
N-(3,4-Methylenedioxyphenylmethyl)-all-trans-retinamide.
Claim 3
Dependent Claim
24 words
A pharmaceutical composition for the treatment of acne by topical application which comprises an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable vehicle.
Claim 4
Dependent Claim
24 words
A pharmaceutical composition for the treatment of acne by topical application which comprises an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable vehicle.
Claim 5
Dependent Claim
20 words
The composition of claim 2 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.01% to about 0.5% by weight of the composition.
Claim 6
Dependent Claim
20 words
The composition of claim 3 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.05% to about 0.2% by weight of the composition.
Claim 7
Dependent Claim
22 words
The composition of claim 2 wherein the vehicle is a mixture selected from the group consisting of propylene glycolethanol and propylene glycol-ethanol-chloroform.
Claim 8
Independent Claim
39 words
A method for treatment of acne in a subject requiring such treatment which comprises topical application to the acne site of said subject of a composition comprising an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable topical vehicle.
Claim 9
Independent Claim
39 words
A method for treatment of acne in a subject requiring such treatment which comprises topical application to the acne site of said subject of a composition comprising an effective acne-treatment amount of N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide admixed with a pharmaceutically-acceptable topical vehicle.
Claim 10
Dependent Claim
20 words
The method of claim 6 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.01% to about 0.5% by weight of the composition.
Claim 11
Dependent Claim
20 words
The method of claim 7 wherein the N-(3,4-methylenedioxyphenylmethyl)-all-trans-retinamide comprises from about 0.05% to about 0.2% by weight of the composition.
Claim 12
Dependent Claim
22 words
The method of claim 6 wherein the vehicle is a mixture selected from the group consisting of propylene glycolethanol and propylene glycol-ethanol-chloroform.
References Cited (Backward Citations)
US3950418A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-20 | 1982-05-22 | 1982-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-20 | 1986-05-22 | 1986-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-20 | 1990-05-22 | 1990-11-21 | $7700.00 | Window Closed / Lapsed |