Cyclopenta (c) pyrrole derivatives

Claim 1

A compound having the formula: ##STR13## where X is O or S; R 1 is hydrogen, lower-alkyl or di-lower-alkylamino-lower-alkyl; R 2 is hydrogen or lower-alkyl; each of R 3 , R 4 and R 5 is hydrogen or methyl; each R 6 group is the same or different hydrogen, formyl and lower-alkane-1,3-diol ketals thereof, phenyl-lower-alkyl, carboxy, carbo-lower-alkoxy, carbo-lower-alkoxy-lower-alkyl, carbo-lower-alkoxy-lower alkenyl, carboxy-lower-alkyl, carboxy-lower-alkenyl, methyl, lower-alkenyl or a group of the formula: ##STR14## where R 8 is hydrogen, lower-alkyl, lower-alkenyl, lower-alkynyl, phenyl or phenyl-lower-alkyl; R 9 is hydrogen, cyano, lower-alkyl, lower-alkenyl, lower-alkynyl, phenyl, phenyl-lower-alkyl, carboxy, carbo-lower-alkoxy, carbamyl, aminomethyl, lower-alkanoyl, trichloromethyl, carbo-lower-alkoxy-lower-alkyl or carbo-lower-alkoxy-lower-alkynyl; R 10 is hydrogen, benzoyl, lower-alkanoyl, carboxy-lower-alkanoyl and ammonium salts thereof, or lower-alkyl, R 10 being other than hydrogen only when either one or both of R 8 and R 9 are hydrogen and R 9 being cyano only when R 10 is hydrogen; and R 7 is hydrogen, lower-alkyl, halo-lower-alkyl, lower-alkenyl, lower-alkynyl, di-lower-alkylamino-lower-alkyl, carbo-lower-alkoxy-lower-alkyl, carboxy-lower-alkyl, carboxamido-lower-alkyl, thiocarboxamido-lower-alkyl, lower-alkoxy-lower-alkyl, hydroxy-lower-alkyl, lower-alkythio-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, phenyl, phenyl-lower-alkyl, or divalent-lower-alkylene having its valences on different carbon atoms and joining two of the 2,4,5,6-tetrahydrocyclopenta[c]pyrrole moieties together, and wherein the phenyl, benzoyl or phenyl-lower-alkyl groups can be further substituted in the phenyl nucleus by a single methylene-dioxy or lower-alkoxy group or by from one to three, the same or different, members of the group consisting of lower-alkyl, halogen, hydroxy, trifluoromethyl, lower-alkanoylamino, amino, di-lower-alkylamino, di-lower-alkylaminomethyl, carboxy, carboxamido, carbo-lower-alkoxy, lower-alkylmercapto, lower-alkylsulfinyl, lower-alkylsulfonyl, nitro and sulfamoyl, and wherein lower-alkyl and lower-alkoxy, each occurrence, contains from one to four carbon atoms; lower-alkane, lower-alkenyl and lower-alkynyl, each occurrence, contain from three to six carbon atoms; lower-alkanoyl, each occurrence, contains from two to five carbon atoms, and lower-alkylene, each occurrence, contains from one to eight carbon atoms, except that both R 6 groups are not simultaneously hydrogen and further except that when R 7 is unsubstituted phenyl and R 6 at the 3-position and R 8 are both hydrogen, R 9 is not unsubstituted-phenyl.