US4125620A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof
Assignee: Boehringer Ingelheim GmbH
•
Filing: 1977-11-11
•
Granted: 1978-11-14
•
Expires: 1997-11-11
Abstract
Abstract Compounds of the formula <IMAGE> wherein Z is 2-ETHYL-6-METHYL-PHENYL, 2,6-DI-TRIFLUOROMETHYL-PHENYL, 2-CHLORO-6-TRIFLUOROMETHYL-PHENYL OR 2-FLUORO-6-TRIFLUOROMETHYL-PHENYL, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS HYPOTENSIVES.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Wolfgang Hoefke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 05:20
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
23 words
A compound of the formula ##STR12## wherein Z is 2-ethyl-6-methyl-phenyl, 2,6-di-trifluoromethyl-phenyl, 2-chloro-6-trifluoromethyl-phenyl or 2-fluoro-6-trifluoromethyl-phenyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
23 words
A compound of the formula ##STR12## wherein Z is 2-ethyl-6-methyl-phenyl, 2,6-di-trifluoromethyl-phenyl, 2-chloro-6-trifluoromethyl-phenyl or 2-fluoro-6-trifluoromethyl-phenyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound of claim 1, which is 2-[(2',6'-ditrifluoromethyl-phenyl)-imino]-imidazolidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
17 words
A compound of claim 1, which is 2-[(2'-ethyl-6'-methyl-phenyl)-imino]-imidazolidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
17 words
A compound of claim 1, which is 2-[(2'-chloro-6'-trifluoromethyl-phenyl)-imino]-imidazolidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
17 words
A compound of claim 1, which is 2-[(2'-fluoro-6'-trifluoromethyl-phenyl)-imino]-imidazolidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
24 words
A hypotensive pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective hypotensive amount of a compound of claim 1.
Claim 8
Dependent Claim
30 words
The method of lowering the blood pressure of a warm-blooded animal in need thereof, which comprises administering to said animal an effective hypotensive amount of a compound of claim 1.
References Cited (Backward Citations)
US2938038A
Cited
US2899426A
Cited
CA772626A
Cited
US3027370A
Cited
US3296077A
Cited
US3190802A
Cited
US3236857A
Cited
GB1034938A
Cited
US3595961A
Cited
GB1180766A
Cited
US3622579A
Cited
US3773767A
Cited
US3931216A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-13 | 1982-05-15 | 1982-11-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-13 | 1986-05-15 | 1986-11-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-13 | 1990-05-15 | 1990-11-14 | $7700.00 | Window Closed / Lapsed |