US4125519A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptides containing 3,4-dihydroxyphenylalanine
Assignee: Individual
•
Filing: 1976-10-13
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Granted: 1978-11-14
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Expires: 1996-10-13
Abstract
Abstract Homopolymers and copolymers containing the amino acid 3,4-dihydroxy-L-phenylalanine (dopa) have been prepared via the synthesis of a protected N-carboxyanhydride (NCA) of the amino acid. These dopa-containing polymers have many uses as in the treatment of Parkinsonism, as drug delivery systems, antioxidants, and fibers and in the production of non-thrombogenic substrates.
Inventors
- 👤 Murray Goodman
- 👤 Michael S. Verlander
- 👤 William D. Fuller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:45
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
23 words
A normally solid linear polymer having as a recurring unit the structure: ##STR6## said polymer having a molecular weight of at least 100,000.
Claim 2
Dependent Claim
23 words
A normally solid linear polymer having as a recurring unit the structure: ##STR6## said polymer having a molecular weight of at least 100,000.
Claim 3
Dependent Claim
11 words
Normally solid poly(3,4-dihydroxy-L-phenylalanine) having a molecular weight of at least 100,000.
Claim 4
Dependent Claim
11 words
Normally solid poly(3,4-dihydroxy-L-phenylalanine) having a molecular weight of at least 100,000.
Claim 5
Dependent Claim
40 words
A normally solid linear copolymer comprising the copolymer of the N-carboxyanhydride derivative of 3,4-dihydroxy-L-phenylalanine having the structure: ##STR7## wherein Q is a protecting group, and a copolymerizable dissimilar alpha-amino acid, said copolymer having a molecular weight of at least 100,000.
Claim 6
Dependent Claim
40 words
A normally solid linear copolymer comprising the copolymer of the N-carboxyanhydride derivative of 3,4-dihydroxy-L-phenylalanine having the structure: ##STR7## wherein Q is a protecting group, and a copolymerizable dissimilar alpha-amino acid, said copolymer having a molecular weight of at least 100,000.
Claim 7
Dependent Claim
57 words
A normally solid, linear copolymer having the structure: ##STR8## wherein R is a substituted or unsubstituted lower alkyl or aryl, Z is H or a suitable protecting group, a and b are integers, the ratio of a to b being in the range of 1:1 to 1:25, said copolymer having a molecular weight of at least 100,000.
Claim 8
Dependent Claim
57 words
A normally solid, linear copolymer having the structure: ##STR8## wherein R is a substituted or unsubstituted lower alkyl or aryl, Z is H or a suitable protecting group, a and b are integers, the ratio of a to b being in the range of 1:1 to 1:25, said copolymer having a molecular weight of at least 100,000.
Claim 9
Dependent Claim
9 words
The copolypeptide of claim 4 wherein Z is H.
Claim 10
Dependent Claim
9 words
The copolypeptide of claim 4 wherein R is ##STR9##
Claim 11
Dependent Claim
15 words
The copolypeptide of claim 4 wherein R is ##STR10## wherein Q is a protecting group.
Claim 12
Dependent Claim
21 words
The copolypeptide of claim 4 wherein the ratio of a to b is in the range of about 1:4 to 1:10.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-13 | 1982-05-15 | 1982-11-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-13 | 1986-05-15 | 1986-11-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-13 | 1990-05-15 | 1990-11-14 | $7700.00 | Window Closed / Lapsed |