US4124527A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions and process for liquid scintillation counting
Assignee: EIDP Inc
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Filing: 1975-12-15
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Granted: 1978-11-07
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Expires: 1995-12-15
Abstract
Abstract Liquid scintillation counting compositions which include certain polyethoxylated poly(oxypropylene) emulsifiers allow stable dispersion of aqueous or other samples merely by shaking. Preferred are mixtures of such emulsifiers, which give homogeneous, monophasic-appearing dispersions over wide ranges of temperature and aqueous sample content. Certain of these emulsifiers, without being mixed, are of particular advantage when used in analysis of samples obtained through radioimmunoassay techniques, which are extremely difficult to disperse. Certain of these emulsifiers, also without being mixed, uniformly give homogeneous, monophasic appearing aqueous counting samples over much wider ranges of aqueous sample content and temperature than prior sample emulsifiers.
Inventors
- 👤 Joel M. Kauffman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:27
CPC Classifications
G; G01; G01T; G01T1/00; G01T1/16; G01T1/20; G01T1/204; G01T1/2042; Y; Y10; Y10S; Y10S436/00; Y10S436/804
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
54 words
A liquid scintillation counting composition, comprising a radioimmunoassay sample and a material having the following structural formula: ##STR2## in which y is from about 18 to about 50, and x and z are such that the total [CH 2 --CH 2 --O] content is from about 10% to 30% by weight of the molecule.
Claim 2
Dependent Claim
54 words
A liquid scintillation counting composition, comprising a radioimmunoassay sample and a material having the following structural formula: ##STR2## in which y is from about 18 to about 50, and x and z are such that the total [CH 2 --CH 2 --O] content is from about 10% to 30% by weight of the molecule.
Claim 3
Dependent Claim
18 words
The composition of claim 1, in which the radioimmunoassay sample comprises inorganic salts and an animal blood fraction.
Claim 4
Dependent Claim
12 words
The composition of claim 1, further comprising at least one organic solvent.
Claim 5
Dependent Claim
10 words
The composition of claim 3, further comprising a scintillating solute.
Claim 6
Dependent Claim
11 words
The composition of claim 4, in which y is about 35.
Claim 7
Dependent Claim
11 words
The composition of claim 4, in which y is about 20.
Claim 8
Independent Claim
92 words
A method of liquid scintillation counting comprising mixing a radioimmunoassay sample to be analyzed with a liquid scintillation composition comprising a mixture of a first material having the following structural formula: ##STR3## in which y is from about 15 to 56 and x and z are from about 1 to about 35, and a second material having the following structural formula: ##STR4## in which y' is from about 15 to about 56 and x' and z' are from about 1 to 35, and exposing the liquid scintillation composition to a scintillation counter.
Claim 9
Independent Claim
92 words
A method of liquid scintillation counting comprising mixing a radioimmunoassay sample to be analyzed with a liquid scintillation composition comprising a mixture of a first material having the following structural formula: ##STR3## in which y is from about 15 to 56 and x and z are from about 1 to about 35, and a second material having the following structural formula: ##STR4## in which y' is from about 15 to about 56 and x' and z' are from about 1 to 35, and exposing the liquid scintillation composition to a scintillation counter.
Claim 10
Independent Claim
64 words
A method of analyzing radioimmunoassay samples, comprising mixing the radioimmunoassay sample to be analyzed with a liquid scintillation composition comprising a material of the following structural formula: ##STR5## in which y is from about 18 to about 50 and x and z are such that the total [CH 2 --CH 2 --O] content is from about 10% to 30% by weight of the molecule.
Claim 11
Independent Claim
64 words
A method of analyzing radioimmunoassay samples, comprising mixing the radioimmunoassay sample to be analyzed with a liquid scintillation composition comprising a material of the following structural formula: ##STR5## in which y is from about 18 to about 50 and x and z are such that the total [CH 2 --CH 2 --O] content is from about 10% to 30% by weight of the molecule.
Claim 12
Dependent Claim
40 words
The method of claim 7, in which y and y' are from about 18 to about 50, and the total [CH 2 --CH 2 --O] contents are from about 10% to about 30% of the total weight in both molecules.
Claim 13
Dependent Claim
22 words
The method of claim 9 in which y is from about 30 to 56 and y' is from about 15 to 30.
Claim 14
Dependent Claim
16 words
The method of claim 10 in which y is about 35 and y' is about 20.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-06 | 1982-05-08 | 1982-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-06 | 1986-05-08 | 1986-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-06 | 1990-05-08 | 1990-11-07 | $7700.00 | Window Closed / Lapsed |