US4123534A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adenine derivatives and hypolipidemic composition thereof
Assignee: Individual
•
Filing: 1977-04-22
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Granted: 1978-10-31
•
Expires: 1997-04-22
Abstract
Abstract Adenine derivatives, their preparation and pharmaceutical compositions containing the same in an amount sufficient to effect hypolipidemia. The derivatives are not inhibitors of C-AMP-phosphodiesterase.
Inventors
- 👤 Karl Credner
- 👤 Gunter Brenner
- 👤 Manfred Tauscher
- 👤 Ljerka Jozic
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:21
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/26; C07D473/32; C07D473/34; A; A61; A61P; A61P3/00; A61P3/06
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
98 words
An acid addition salt of an amine of the formula: ##STR16## wherein R 1 is alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms; hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and an acid selected from the group consisting of 3-methylpyrazole-5-carboxylic acid, 3-methylisoxazole-5-carboxylic acid, acetylsalicylic acid, clofibric acid, nicotinic acid, fusaric acid, theophyllinyl-7-acetic acid, orotic acid, 5-chloroindole-2-carboxylic acid, 5-methylisoxozole-3-carboxylic acid, 3,4,5,-trimethoxybenzoic acid and flufenamic acid.
Claim 2
Dependent Claim
98 words
An acid addition salt of an amine of the formula: ##STR16## wherein R 1 is alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms; hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and an acid selected from the group consisting of 3-methylpyrazole-5-carboxylic acid, 3-methylisoxazole-5-carboxylic acid, acetylsalicylic acid, clofibric acid, nicotinic acid, fusaric acid, theophyllinyl-7-acetic acid, orotic acid, 5-chloroindole-2-carboxylic acid, 5-methylisoxozole-3-carboxylic acid, 3,4,5,-trimethoxybenzoic acid and flufenamic acid.
Claim 3
Dependent Claim
11 words
A salt according to claim 1 wherein R 1 is 2-hydroxyethyl.
Claim 4
Dependent Claim
19 words
A salt according to claim 2 wherein R 2 is hydrogen or alkyl of 1 to 4 carbon atoms.
Claim 5
Dependent Claim
17 words
A salt according to claim 2 wherein R 2 is hydrogen, methyl, ethyl, isopropyl, n-butyl or 2-hydroxyethyl.
Claim 6
Dependent Claim
12 words
A salt according to claim 2 wherein said acid is 3-methylpyrazole-5-carboxylic acid.
Claim 7
Dependent Claim
11 words
A salt according to claim 1 wherein said amine is 6-amino-9-[2-hydroxy-3-(N-methyl-N-2-hydroxyethylamino)propyl]-purine.
Claim 8
Dependent Claim
11 words
A salt according to claim 1 wherein said amine is 6-amino-7-[2-hydroxy-3-(N-methyl-N-2-hydroxyethylamino)propyl]-purine.
Claim 9
Dependent Claim
12 words
A salt according to claim 1 wherein said acid in 3-methylpyrazole-5-carboxylic acid.
Claim 10
Dependent Claim
22 words
A pharmaceutical composition comprising a hypolipidemically effective amount of a salt according to claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
24 words
A composition according to claim 9 in an orally administerable unit dose form, said composition containing from 0.25 to 100 mg of said salt.
Claim 12
Dependent Claim
15 words
A composition according to claim 10 containing from 0.5 to 50 mg of said salt.
Claim 13
Dependent Claim
23 words
The method of reducing hyperlipidemia in an animal which comprises administering thereto a hypolipidemically effective amount of a salt according to claim 1.
Claim 14
Dependent Claim
59 words
An amine of the formula: ##STR17## wherein R 1 is alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms; hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms.
Claim 15
Dependent Claim
59 words
An amine of the formula: ##STR17## wherein R 1 is alkyl of 1 to 4 carbon atoms, hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms; hydroxyalkyl of 2 to 4 carbon atoms or alkoxyalkyl of 2 to 6 carbon atoms.
References Cited (Backward Citations)
US3412093A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-30 | 1982-05-01 | 1982-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-30 | 1986-05-01 | 1986-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-30 | 1990-05-01 | 1990-10-31 | $7700.00 | Window Closed / Lapsed |