US4123497A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purification of Technetium-99m pertechnetate solutions
Assignee: GE Healthcare Ltd
•
Filing: 1976-02-25
•
Granted: 1978-10-31
•
Expires: 1996-02-25
Abstract
Abstract The invention provides a method and apparatus for preparing aqueous solutions of technetium-99m pertechnetate. In a preferred embodiment, the eluate from a technetium-99m generator is contacted with a cation-exchange resin having adsorbed thereon a cation which forms an insoluble salt with the anion of the generator eluate, whereby there is obtained an aqueous solution of the pertechnetate in water. The solution may be concentrated by adsorption of the pertechnetate on alumina, followed by desorption using a smaller volume of aqueous electrolyte.
Inventors
- 👤 Clinton F. Ruddock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:41
CPC Classifications
G; G21; G21F; G21F9/00; G21F9/04; G21F9/06; G21F9/12; G21G; G21G1/00; G21G1/0005; C; C02; C02F; C02F1/00; C02F1/42; G21G1/001; G21G4/00; G21G4/04; G21G4/06; G21G4/08; A; A61; A61K; A61K2123/00; C02F2001/422
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
87 words
A method of preparing a solution of pertechnetate ion in water, which method comprises the steps of: (1) providing an aqueous electrolyte containing cations and anions and containing technetium-99m in the form of pertechnetate ion TcO 4 - ; and (2) contacting the electrolyte with a cation-exchange material having adsorbed on cation-exchange sites thereof a cation which forms an insoluble salt with said anions in said aqueous electrolyte, whereby there is obtained an aqueous solution of the pertechnetate which is otherwise substantially free of cations and anions.
Claim 2
Independent Claim
87 words
A method of preparing a solution of pertechnetate ion in water, which method comprises the steps of: (1) providing an aqueous electrolyte containing cations and anions and containing technetium-99m in the form of pertechnetate ion TcO 4 - ; and (2) contacting the electrolyte with a cation-exchange material having adsorbed on cation-exchange sites thereof a cation which forms an insoluble salt with said anions in said aqueous electrolyte, whereby there is obtained an aqueous solution of the pertechnetate which is otherwise substantially free of cations and anions.
Claim 3
Dependent Claim
29 words
A method as claimed in claim 1 wherein the aqueous electrolyte is obtained in step (1) by passing an aqueous eluant containing cations and anions through a technetium-99m generator.
Claim 4
Dependent Claim
15 words
A method as claimed in claim 2, wherein the generator eluant is aqueous saline solution.
Claim 5
Dependent Claim
15 words
A method as claimed in claim 1, wherein the cation-exchange material is a cation-exchange resin.
Claim 6
Dependent Claim
19 words
A method as claimed in claim 1, wherein the cation adsorbed on the cation-exchange material is Ag + .
Claim 7
Dependent Claim
33 words
A method as claimed in claim 1 wherein, in step (2) the cation-exchange material is washed, after being contacted with the aqueous electrolyte, so as to ensure the complete removal of the pertechnetate.
Claim 8
Dependent Claim
20 words
a method as claimed in claim 1 wherein, the resulting aqueous solution of pertechnetate is concentrated by the steps of:
Claim 9
Dependent Claim
16 words
(3) contacting the said aqueous solution with a material to releasably adsorb the pertechnetate therefrom and
Claim 10
Dependent Claim
16 words
(3) contacting the said aqueous solution with a material to releasably adsorb the pertechnetate therefrom and
Claim 11
Dependent Claim
25 words
(4) contacting the material carrying the pertechnetate with a desired volume of an aqueous electrolyte and thereby recovering a solution of pertechnetate of desired concentration.
Claim 12
Dependent Claim
25 words
(4) contacting the material carrying the pertechnetate with a desired volume of an aqueous electrolyte and thereby recovering a solution of pertechnetate of desired concentration.
Claim 13
Dependent Claim
21 words
A method as claimed in claim 7, wherein the material used in step (3) to releasably adsorb the pertechnetate is alumina.
Claim 14
Dependent Claim
23 words
A method as claimed in claim 7, wherein the aqueous electrolyte used in step (4) to recover the pertechnetate is isotonic silane solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-30 | 1982-05-01 | 1982-10-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-30 | 1986-05-01 | 1986-10-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-30 | 1990-05-01 | 1990-10-31 | $7700.00 | Window Closed / Lapsed |