US4122186A
Expired / Lapsed
US
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Acetohydroxamic acids
Assignee: Cephalon France SAS
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Filing: 1977-03-17
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Granted: 1978-10-24
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Expires: 1997-03-17
Abstract
Abstract The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R1R2R3C-CO-NHOH, in which R2 and R3 are each hydrogen or C1-6 alkyl, and R1 is C1-6 alkyl Z1Z2 N (where Z1 and Z2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z3CH2- (where Z3 = optionally substituted aryl), Z4-A- (where Z4 is optionally substituted phenyl or naphthyl, and A is -NH-, -N(C1-4 alkyl)-, -N(C5-6 cycloalkyl)-, -NHCO-, -N(C1-4 alkyl)CO-, -N(C5-6 cycloalkyl)CO-, -CONH-, -CON(C1-4 alkyl)-, -CON(C5-6 cycloalkyl)-, -NHCONH-, -N(C5H6)CONH-, or -N(substituted phenyl)CONH-, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.
Inventors
- 👤 Louis Lafon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:53
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/14; C07D295/145; C07D295/15; A; A61; A61P; A61P25/00; A61P25/08; C07C; C07C275/00; C07C275/28; C07C275/30; C07C323/00; C07C57/00; C07C57/64; C07C57/72; C07D223/00; C07D223/14; C07D223/18; C07D223/22; C07D233/00; C07D233/54; C07D233/66; C07D233/72; C07D233/74; C07D233/76; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D235/16; C07D279/00; C07D279/10; C07D279/14; C07D279/18; C07D279/22; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/56
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
110 words
An acetohydroxamic acid of the formula: ##STR80## (in which R 2 and R 3 , which may be identical or different, each represent the hydrogen atom or a C 1 -C 6 alkyl group, Z 1 and Z 2 , which may be identical or different, each represent a C 5 -C 6 cycloalkyl group, a phenyl group or a phenyl group substituted by one or more C 1 -C 4 -alkyl groups, C 1 -C 4 -alkoxy groups, halogen, CF 3 , NO 2 or NH 2 groups), its metal salts and acid addition salts when one or both of Z 1 and Z 2 contains a basic group.
Claim 2
Dependent Claim
110 words
An acetohydroxamic acid of the formula: ##STR80## (in which R 2 and R 3 , which may be identical or different, each represent the hydrogen atom or a C 1 -C 6 alkyl group, Z 1 and Z 2 , which may be identical or different, each represent a C 5 -C 6 cycloalkyl group, a phenyl group or a phenyl group substituted by one or more C 1 -C 4 -alkyl groups, C 1 -C 4 -alkoxy groups, halogen, CF 3 , NO 2 or NH 2 groups), its metal salts and acid addition salts when one or both of Z 1 and Z 2 contains a basic group.
Claim 3
Dependent Claim
35 words
A compound according to claim 1, in which Z 1 = Z 2 = cyclohexyl, phenyl or halogenophenyl, R 2 = H, CH 3 or C 2 H 5 , and R 3 = H.
Claim 4
Dependent Claim
6 words
N,N-Diphenylcarbamoyl-acetohydroxamic acid and its metal salts.
Claim 5
Dependent Claim
6 words
N,N-Diphenylcarbamoyl-acetohydroxamic acid and its metal salts.
Claim 6
Dependent Claim
6 words
2-(N,N-Diphenylcarbamoyl)-propionohydroxamic acid and its metal salts.
Claim 7
Dependent Claim
6 words
2-(N,N-Diphenylcarbamoyl)-propionohydroxamic acid and its metal salts.
Claim 8
Dependent Claim
6 words
2-(N,N-Diphenylcarbamoyl)-butyrohydroxamic acid and its metal salts.
Claim 9
Dependent Claim
6 words
2-(N,N-Diphenylcarbamoyl)-butyrohydroxamic acid and its metal salts.
Claim 10
Dependent Claim
6 words
N,N-Dicyclohexylcarbamoyl-acetohydroxamic acid and its metal salts.
Claim 11
Dependent Claim
6 words
N,N-Dicyclohexylcarbamoyl-acetohydroxamic acid and its metal salts.
Claim 12
Dependent Claim
31 words
A pharmaceutical composition, comprising, in association with a pharmaceutically acceptable excipient, at least one compound according to claim 1, or one of its non-toxic metal salts or addition salts with acids.
References Cited (Backward Citations)
GB894119A
Cited
US3728380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-23 | 1982-04-24 | 1982-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-23 | 1986-04-24 | 1986-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-23 | 1990-04-24 | 1990-10-24 | $7700.00 | Window Closed / Lapsed |