US4122176A
Expired / Lapsed
US
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3-(Piperazinoalkyl)-benz-2,1-isoxazoles
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1976-12-29
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Granted: 1978-10-24
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Expires: 1996-12-29
Abstract
Abstract Novel benzisoxazole compounds of the formula: ##STR1## wherein R 1 and R 2 are each hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, ar(C 1 14 C 3 ) alkoxy or halogen or, when taken together, they form C 1 -C 2 alkylenedioxy, Alk is C 1 -C 4 alkylene and A is a group of the formula: ##STR2## (wherein R 3 and R 4 are each C 1 -C 4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R 5 is C 1 -C 4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.
Inventors
- 👤 Junki Katsube
- 👤 Tsuyoshi Kobayashi
- 👤 Katsumi Tamoto
- 👤 Yoshiaki Takebayashi
- 👤 Kikuo Sasajima
- 👤 Shigeho Inaba
- 👤 Hisao Yamamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:58
CPC Classifications
C; C07; C07D; C07D261/00; C07D261/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
108 words
A compound of the formula: ##STR8## wherein R 1 ' and R 2 ' are each hydrogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, phenyl(C 1 -C 3 )alkoxy or halogen or, when taken together, R 1 ' and R 2 ' form C 1 -C 2 alkylenedioxy, Alk' is alkylene having 1 to 4 carbon atoms and A is a group of the formula: ##STR9## wherein R 5 ' is an alkyl group having 1 to 4 carbon atoms, phenyl or phenyl substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halogen.
Claim 2
Dependent Claim
108 words
A compound of the formula: ##STR8## wherein R 1 ' and R 2 ' are each hydrogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, phenyl(C 1 -C 3 )alkoxy or halogen or, when taken together, R 1 ' and R 2 ' form C 1 -C 2 alkylenedioxy, Alk' is alkylene having 1 to 4 carbon atoms and A is a group of the formula: ##STR9## wherein R 5 ' is an alkyl group having 1 to 4 carbon atoms, phenyl or phenyl substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halogen.
Claim 3
Dependent Claim
80 words
A compound of the formula: ##STR10## wherein R 1 ' and R 2 ' are each hydrogen, C 1 -C 2 alkoxy or halogen or, when taken together, R 1 ' and R 2 ' form C 1 -C 2 alkylenedioxy, Alk' is C 2 -C 3 alkylene and R 5 ' is C 1 -C 2 alkyl phenyl or phenyl substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halogen, or a non-toxic salt thereof.
Claim 4
Dependent Claim
80 words
A compound of the formula: ##STR10## wherein R 1 ' and R 2 ' are each hydrogen, C 1 -C 2 alkoxy or halogen or, when taken together, R 1 ' and R 2 ' form C 1 -C 2 alkylenedioxy, Alk' is C 2 -C 3 alkylene and R 5 ' is C 1 -C 2 alkyl phenyl or phenyl substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halogen, or a non-toxic salt thereof.
Claim 5
Dependent Claim
6 words
3-[2'-(4"-Phenylpiperazino)ethyl]-5,6-dimethoxy-benz-2,1-isoxazole or a non-toxic salt thereof.
Claim 6
Dependent Claim
6 words
3-[2'-(4"-Phenylpiperazino)ethyl]-5,6-dimethoxy-benz-2,1-isoxazole or a non-toxic salt thereof.
Claim 7
Dependent Claim
31 words
A pharmaceutical composition consisting essentially of an effective central nervous system depressing or bronchodilating amount of the compound of claim 2, and at least one pharmaceutically acceptacle inert carrier or diluent.
Claim 8
Dependent Claim
34 words
A method for inducing a central nervous system depressing or bronchodilating effect in animals or human beings, which comprises administering thereto an amount of the compound of claim 2 effective to induce said effect.
Claim 9
Dependent Claim
31 words
A pharmaceutical composition consisting essentially of an effective central nervous system depressing or bronchodilating amount of the compound of claim 1, and at least one pharmaceutically acceptable inert carrier or diluent.
Claim 10
Dependent Claim
34 words
A method for inducing a central nervous system depressing or bronchodilating effect in animals or human beings, which comprises administering thereto an amount of the compound of claim 1 effective to induce said effect.
Claim 11
Dependent Claim
32 words
A pharmaceutical composition consisting essentially of an effective central nervous system depressing or bronchodilating amount of 3-[2'-(4"-phenylpiperazino)ethyl]-5,6-dimethoxy-benz-2,1-isoxazole, or a non-toxic salt thereof, and at least one pharmaceutically acceptable inert carrier or diluent.
Claim 12
Dependent Claim
32 words
A pharmaceutical composition consisting essentially of an effective central nervous system depressing or bronchodilating amount of 3-[2'-(4"-phenylpiperazino)ethyl]-5,6-dimethoxy-benz-2,1-isoxazole, or a non-toxic salt thereof, and at least one pharmaceutically acceptable inert carrier or diluent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-23 | 1982-04-24 | 1982-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-23 | 1986-04-24 | 1986-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-23 | 1990-04-24 | 1990-10-24 | $7700.00 | Window Closed / Lapsed |