US4120951A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptide hormones of the thymus
Assignee: Memorial Sloan Kettering Cancer Center
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Filing: 1977-05-09
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Granted: 1978-10-17
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Expires: 1997-05-09
Abstract
Abstract There are disclosed closely related new polypeptides isolated from bovine thymus, which are distinct polypeptides denoted as Thymin I and Thymin II or Thymopoietin I and Thymopoietin II, respectively. Thymin I may be characterized as having a relative mobility (Rf) on 7% polyacrylamide gel disc electrophoresis of 0.63 with respect to methyl green at a pH of 4.3, and having the following structural sequence:
Inventors
- 👤 Gideon Goldstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:27
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/66; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/18
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
21 words
A therapeutic composition of matter comprising a therapeutically effective amount of the polypeptide: H 2 n--gly--gln--phe--leu--glu--asp--pro--ser--val--leu--thr--lys--glu--lys--leu--lys--ser--glu--leu--val--ala--asn--asn--val--thr--leu--pro--ala--gly--glu--gln--arg--lys--asp--val--tyr--val--gln--leu--tyr--leu--gln--his--leu--thr--ala--val--lys--arg--cooh, in a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
21 words
A therapeutic composition of matter comprising a therapeutically effective amount of the polypeptide: H 2 n--gly--gln--phe--leu--glu--asp--pro--ser--val--leu--thr--lys--glu--lys--leu--lys--ser--glu--leu--val--ala--asn--asn--val--thr--leu--pro--ala--gly--glu--gln--arg--lys--asp--val--tyr--val--gln--leu--tyr--leu--gln--his--leu--thr--ala--val--lys--arg--cooh, in a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
23 words
A therapeutic composition according to claim 1 wherein the therapeutically effective amount of polypeptide is at least about 0.20 μg/kg of body weight.
Claim 4
Dependent Claim
21 words
A therapeutic composition of matter comprising a therapeutically effective amount of the polypeptide: H 2 n--ser--gln--phe--leu--glu--asp--pro--ser--val--leu--thr--lys--glu--lys--leu--lys--ser--glu--leu--val--ala--asn--asn--val--thr--leu--pro--ala--gly--glu--gln--arg--lys--asp--val--tyr--val--gln--leu--tyr--leu--gln--thr--leu--thr--ala--val--lys--arg--cooh, in a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
21 words
A therapeutic composition of matter comprising a therapeutically effective amount of the polypeptide: H 2 n--ser--gln--phe--leu--glu--asp--pro--ser--val--leu--thr--lys--glu--lys--leu--lys--ser--glu--leu--val--ala--asn--asn--val--thr--leu--pro--ala--gly--glu--gln--arg--lys--asp--val--tyr--val--gln--leu--tyr--leu--gln--thr--leu--thr--ala--val--lys--arg--cooh, in a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
23 words
A therapeutic composition according to claim 3 wherein the therapuetically effective amount of polypeptide is at least about 1.3 μg/kg of body weight.
Claim 7
Dependent Claim
29 words
A method for the treatment of conditions resulting from relative or absolute T cell deficiencies which comprises administration of a pharmaceutically effective amount of the composition of claim 1.
Claim 8
Dependent Claim
29 words
A method for the treatment of conditions resulting from relative or absolute T cell deficiencies which comprises administration of a pharmaceutically effective amount of the composition of claim 3.
Claim 9
Dependent Claim
28 words
A method for inducing bone marrow cells to develop the characteristics of thymus-derived lymphocytes which comprises administration of a therapeutically effective amount of the composition of claim 1.
Claim 10
Dependent Claim
28 words
A method for inducing bone marrow cells to develop the characteristics of thymus-derived lymphocytes which comprises administration of a therapeutically effective amount of the composition of claim 3.
Claim 11
Dependent Claim
37 words
A method for affecting the immune response in the body to assist in the correction of relative or absolute deficiencies of the thymus which comprises administration of a therapeutically effective amount of the composition of claim 1.
Claim 12
Dependent Claim
37 words
A method for affecting the immune response in the body to assist in the correction of relative or absolute deficiencies of the thymus which comprises administration of a therapeutically effective amount of the composition of claim 3.
Claim 13
Dependent Claim
26 words
A method for the treatment of conditions resulting from excess neuromuscular activity which comprises administration of a therapeutically effective amount of the composition of claim 1.
Claim 14
Dependent Claim
26 words
A method for the treatment of conditions resulting from excess neuromuscular activity which comprises administration of a therapeutically effective amount of the composition of claim 3.
Claim 15
Dependent Claim
25 words
A method for inhibiting the uncontrolled proliferation of thymin-responsive lymphocytes which comprises a administration of a therapeutically effective amount of the composition of claim 1.
Claim 16
Dependent Claim
24 words
A method for inhibiting the uncontrolled proliferation of thymin-responsive lymphocytes which comprises administration of a therapeutically effective amount of the composition of claim 3.
Claim 17
Dependent Claim
26 words
A method for enhancing the cellular immune responses mediated by T cells which comprises administration of a therapeutically effective amount of the composition of claim 1.
Claim 18
Dependent Claim
26 words
A method for enhancing the cellular immune responses mediated by T cells which comprises administration of a therapeutically effective amount of the composition of claim 3.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-16 | 1982-04-17 | 1982-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-16 | 1986-04-17 | 1986-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-16 | 1990-04-17 | 1990-10-17 | $7700.00 | Window Closed / Lapsed |