US4119723A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of rheumatoid arthritis and related diseases
Assignee: Individual
•
Filing: 1977-07-08
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Granted: 1978-10-10
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Expires: 1997-07-08
Abstract
Abstract It is believed that rheumatoid arthritis and related collagen and auto-immune diseases are an infection and that various species of free-living (limax) amoebae are the aetiological agent of these diseases. It has been discovered that tinidazole and related compounds, antimycotic drugs with anti-protozoal activity, are effective for the treatment of rheumatoid arthritis and other collagen and auto-immune (rheumatoid) diseases.
Inventors
- 👤 Roger Wyburn-Mason
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
56 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering orally to such a patient an effective amount of a compound of the formula: ##STR3## wherein R and R' are each alkylene having 1 to 7 carbon atoms and X is lower alkylsulfonyl and the pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
56 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering orally to such a patient an effective amount of a compound of the formula: ##STR3## wherein R and R' are each alkylene having 1 to 7 carbon atoms and X is lower alkylsulfonyl and the pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein R is alkylene having 1 to 7 carbon atoms, X is lower alkylsulfonyl and R' is methylene.
Claim 4
Dependent Claim
15 words
The method according to claim 1 wherein the compound is tinidazole having the formula: ##STR4##
Claim 5
Dependent Claim
31 words
The method of claim 1, wherein the compound is tinidazole having the formula: ##STR5## and is administered orally in doses of approximately 35 mg. per kilogram of body weight per week.
Claim 6
Dependent Claim
35 words
The method of combating rheumatoid arthritis of claim 4 which comprises orally administering to the infected subject tinidazole in a weekly dose amount of about 20 to about 50 miligrams per kilogram of body weight.
References Cited (Backward Citations)
US3376311A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-09 | 1982-04-10 | 1982-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-09 | 1986-04-10 | 1986-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-09 | 1990-04-10 | 1990-10-10 | $7700.00 | Window Closed / Lapsed |