US4119590A
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Process for producing a polyion complex having a nucleic acid base
Assignee: Tosoh Corp
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Filing: 1977-06-22
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Granted: 1978-10-10
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Expires: 1997-06-22
Abstract
Abstract A polyion complex is produced by reacting a weak acid type or a strong acid type polyanion polymer with a nucleic acid base-containing polycation polymer.
Inventors
- 👤 Toru Seita
- 👤 Akihiko Shimizu
- 👤 Yujiro Kosaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 14:43
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0002; B01D67/0006; B01D71/00; B01D71/06; B01D71/76; B01D71/80; C; C08; C08J; C08J3/00; C08J3/24; C08J3/246; C08L; C08L25/00; C08L25/18; C08L33/00; C08L33/04; C08L33/14; C08L39/00; C08L39/04; Y; Y10; Y10S; Y10S526/00; Y10S526/936
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
139 words
A process for producing a polyion complex which comprises reacting a polyanion polymer with a nucleic acid base-containing polycation polymer having the unit formula ##STR19## wherein R 1 is a hydrogen atom or a C 1-4 alkyl group; R 2 and R 3 are each a C 1-10 hydrocarbon group; R 4 is a hydrogen atom or a methyl group; R 5 is a C 1-6 alkyl group; R 6 and R 7 are each a C 1-4 alkyl group; M is a vinyl monomer; x is 0 -450,000; Z is a halogen atom or an hydroxyl group; y is 0 or 1; n is an integer higher than 10; X is adenine, thymine, cytosine, uracil or a derivative thereof in which a purine nucleus is bonded to the 9-position and a pyrimidine nucleus is bonded to the 1-position.
Claim 2
Dependent Claim
139 words
A process for producing a polyion complex which comprises reacting a polyanion polymer with a nucleic acid base-containing polycation polymer having the unit formula ##STR19## wherein R 1 is a hydrogen atom or a C 1-4 alkyl group; R 2 and R 3 are each a C 1-10 hydrocarbon group; R 4 is a hydrogen atom or a methyl group; R 5 is a C 1-6 alkyl group; R 6 and R 7 are each a C 1-4 alkyl group; M is a vinyl monomer; x is 0 -450,000; Z is a halogen atom or an hydroxyl group; y is 0 or 1; n is an integer higher than 10; X is adenine, thymine, cytosine, uracil or a derivative thereof in which a purine nucleus is bonded to the 9-position and a pyrimidine nucleus is bonded to the 1-position.
Claim 3
Dependent Claim
14 words
The process of claim 1, wherein the polycation polymer has the unit formula ##STR20##
Claim 4
Dependent Claim
14 words
The process of claim 1, wherein the polycation polymer has the unit formula ##STR21##
Claim 5
Dependent Claim
52 words
The process of claim 1, wherein the polyanion polymer is selected from the group consisting of polystyrenesulfonic acid polymers, polyvinylsulfonic acid polymers, polymaleic acid polymers, copolymers of acrylic acid, methacrylic acid or maleic acid, carboxymethyl cellulose polymers, alginic acid polymers, poly-L-aspartic acid polymers and poly-L-glutamic acid polymers and alkali metal salts thereof.
Claim 6
Dependent Claim
38 words
The process of claim 1, wherein the polyanion polymer and the polycation polymer are respectively dissolved in a solvent of water, a water miscible solvent or a mixture thereof, both solutions are admixed and the precipitate is collected.
Claim 7
Dependent Claim
18 words
The process of claim 5, wherein said solvent is water, methanol, ethanol, butanol, acetone, tetrahydrofuran or N, N'-dimethylformamide.
Claim 8
Dependent Claim
27 words
The process of claim 1, wherein the equivalent ratio of the polycation polymer relative to the polyanion polymer is in the range of from 0.05 to 20.
Claim 9
Dependent Claim
14 words
The process of claim 1, wherein the polycation polymer has the unit formula ##STR22##
Claim 10
Dependent Claim
14 words
The process of claim 1, wherein the polycation polymer has the unit formula ##STR23##
Claim 11
Dependent Claim
10 words
The polyion complex prepared by the process of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-09 | 1982-04-10 | 1982-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-09 | 1986-04-10 | 1986-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-09 | 1990-04-10 | 1990-10-10 | $7700.00 | Window Closed / Lapsed |