US4118380A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Decapeptide analogs of somatostatin
Assignee: Wyeth Canada Inc
•
Filing: 1977-07-25
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Granted: 1978-10-03
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Expires: 1997-07-25
Abstract
Abstract Compounds of the formula 1 or 1a ##STR1## HSCH.sub.2 CH.sub.2 CO-A-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-NHCH.sub.2 CH 2 SH (1a) in which A is Gly-Asn or Lys-Gly, or therapeutically acceptable salts thereof are disclosed. The compounds of formulae 1 and 1a are useful for the management of diabetes and the treatment of acromegaly in mammals. Compositions and methods for their use also are disclosed.
Inventors
- 👤 Hans U. Immer
- 👤 Nedumparambil A. Abraham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 13:08
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
18 words
A compound of the formula 1 ##STR10## in which A is Gly-Asn or a therapeutically acceptable salt thereof.
Claim 2
Dependent Claim
18 words
A compound of the formula 1 ##STR10## in which A is Gly-Asn or a therapeutically acceptable salt thereof.
Claim 3
Dependent Claim
23 words
A compound of the formula 1a HSCH.sub.2 CH.sub.2 C0-A-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-NHCH.sub.2 CH.sub.2 SH (1a) in which A is Gly-Asn or a therapeutically acceptable salt thereof.
Claim 4
Dependent Claim
23 words
A compound of the formula 1a HSCH.sub.2 CH.sub.2 C0-A-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-NHCH.sub.2 CH.sub.2 SH (1a) in which A is Gly-Asn or a therapeutically acceptable salt thereof.
Claim 5
Dependent Claim
13 words
A compound of the formula 5 ##STR11## in which A 1 is Gly-Asn.
Claim 6
Dependent Claim
13 words
A compound of the formula 5 ##STR11## in which A 1 is Gly-Asn.
Claim 7
Dependent Claim
18 words
A compound of the formula 4 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-Trp-Lys(Boc)-Thr(Bu.sup.t)-Phe-Thr(Bu.sup.t)-Ser(Bu.sup.t)-NHCH.sub.2 CH.sub.2 S-Trt in which A 1 is Gly-Asn.
Claim 8
Dependent Claim
18 words
A compound of the formula 4 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-Trp-Lys(Boc)-Thr(Bu.sup.t)-Phe-Thr(Bu.sup.t)-Ser(Bu.sup.t)-NHCH.sub.2 CH.sub.2 S-Trt in which A 1 is Gly-Asn.
Claim 9
Dependent Claim
18 words
A compound of the formula 2 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-NHNH.sub.2 ( 2) in which A 1 is Gly-Asn.
Claim 10
Dependent Claim
18 words
A compound of the formula 2 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-NHNH.sub.2 ( 2) in which A 1 is Gly-Asn.
Claim 11
Dependent Claim
16 words
A compound of the formula 7 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-OMe (7) which A 1 is Gly-Asn.
Claim 12
Dependent Claim
16 words
A compound of the formula 7 Trt-SCH.sub.2 CH.sub.2 CO-A.sup.1 -Phe-Phe-OMe (7) which A 1 is Gly-Asn.
Claim 13
Dependent Claim
31 words
A pharmaceutical composition which comprises a compound of the formula 1 or a therapeutically acceptable salt thereof, as claimed in claim 1, and a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 14
Dependent Claim
38 words
A method of treating acromegaly or of managing diabetes in mammals, which comprises administering to said mammal an effective dose of a compound of the formula 1 or a therapeutically acceptable salt thereof, as claimed in claim 1.
Claim 15
Dependent Claim
31 words
A pharmaceutical composition which comprises a compound of the formula 1a or a therapeutically acceptable salt thereof, as claimed in claim 2, and a pharmaceutically acceptable liquid or solid carrier therefor.
Claim 16
Dependent Claim
38 words
A method of treating acromegaly or of managing diabetes in mammals, which comprises administering to said mammal an effective dose of a compound of the formula 1a or a therapeutically acceptable salt thereof, as claimed in claim 2.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-02 | 1982-04-03 | 1982-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-02 | 1986-04-03 | 1986-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-02 | 1990-04-03 | 1990-10-03 | $7700.00 | Window Closed / Lapsed |