US4116046A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liquid chromatography system
Assignee: Hoffmann La Roche Inc
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Filing: 1977-08-05
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Granted: 1978-09-26
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Expires: 1997-08-05
Abstract
Abstract A liquid chromatography system comprises the following major components in combination: gas pressurized buffer reservoirs, automatic buffer selection valve, mixer/debubbler chamber, pump means, automatic sample valve, chromatography column, detector and fraction collector.
Inventors
- 👤 Stanley Stein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 10:06
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/04; G01N30/24
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
140 words
A fully automated liquid-column chromatography system comprising in combination: A. a plurality of gas pressurized buffer reservoir means; B. an automatic, programmable buffer selection valve means whereby controlled sequential buffer flow from said buffer reservoir means is obtained; C. mixer-debubbler, chamber means downstream of said buffer selection value means whereby a concentration gradient may be established between said buffers and said buffer stream is concomitantly debubbled; D. pump means whereby the flow rate of said buffers is controlled; E. automatic sample valve means downstream of said pump means whereby samples are injected into said buffer stream in a sequential manner; F. liquid chromatography column means whereby components in said samples are separated and passed into a column effluent stream; G. detection means for identifying the presence of said sample components in the column effluent stream; and H. fraction collection means.
Claim 2
Dependent Claim
140 words
A fully automated liquid-column chromatography system comprising in combination: A. a plurality of gas pressurized buffer reservoir means; B. an automatic, programmable buffer selection valve means whereby controlled sequential buffer flow from said buffer reservoir means is obtained; C. mixer-debubbler, chamber means downstream of said buffer selection value means whereby a concentration gradient may be established between said buffers and said buffer stream is concomitantly debubbled; D. pump means whereby the flow rate of said buffers is controlled; E. automatic sample valve means downstream of said pump means whereby samples are injected into said buffer stream in a sequential manner; F. liquid chromatography column means whereby components in said samples are separated and passed into a column effluent stream; G. detection means for identifying the presence of said sample components in the column effluent stream; and H. fraction collection means.
Claim 3
Dependent Claim
27 words
The system of claim 1 wherein said mixer-debubbler chamber means contains a magnetic spin bar which is activated by a magnetic stirrer located directly below said chamber.
Claim 4
Dependent Claim
18 words
The system of claim 1 wherein said mixer-debubbler chamber means contains gas removal means and liquid removal means.
Claim 5
Dependent Claim
21 words
The system of claim 1 wherein said mixer-debubbler chamber has a volume in the range of from 0.1 to 50 ml.
Claim 6
Dependent Claim
16 words
The system of claim 1 wherein a pressure gauge is present downstream of said pump means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-25 | 1982-03-27 | 1982-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-25 | 1986-03-27 | 1986-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-25 | 1990-03-27 | 1990-09-26 | $7700.00 | Window Closed / Lapsed |