US4115555A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones
Assignee: ER Squibb and Sons LLC
•
Filing: 1977-07-05
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Granted: 1978-09-19
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Expires: 1997-07-05
Abstract
Abstract Compounds of the following formula ##STR1## wherein R 1 and R 2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 ad R 3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.
Inventors
- 👤 Peter C. Wade
- 👤 Berthold Richard Vogt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:01
CPC Classifications
C; C07; C07D; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/14; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/048
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
50 words
A compound of the formula: ##STR16## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower alkylthio, nitro, cyano, and trifluoromethyl; and R is selected from the group consisting of triacetyl substituted pentose, pentose, tetraacetyl substituted hexose, and hexose.
Claim 2
Dependent Claim
50 words
A compound of the formula: ##STR16## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower alkylthio, nitro, cyano, and trifluoromethyl; and R is selected from the group consisting of triacetyl substituted pentose, pentose, tetraacetyl substituted hexose, and hexose.
Claim 3
Dependent Claim
43 words
The compound of claim 1 having the formula: ##STR17## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, Cl, Br, F, methyl and methoxy and are located at the 7- or 8-position and 5- or 6-position respectively.
Claim 4
Dependent Claim
39 words
The compound of claim 2 wherein said pentose is selected from the group consisting of D-ribose, D-arabinose, D-xylose, and D-lyxose and said hexose is selected from the group consisting of D-glucose, D-allose, D-gulose, D-galactose, D-altrose, D-mannose, D-idose, and D-talose.
Claim 5
Dependent Claim
22 words
The compound of claim 3 wherein R is D-glucose or tetraacetyl substituted D-glucose and R 1 and R 2 are both hydrogen.
Claim 6
Dependent Claim
8 words
The compound of claim 4, 2-β-D-glucosyl-1H-benz[de]isoquinoline-1,3(2H)-dione, tetraacetate ester.
Claim 7
Dependent Claim
6 words
The compound of claim 4, 2-β-D-glucosyl-1H-benz[de]isoquinoline-1,3(2H)-dione.
Claim 8
Dependent Claim
39 words
A pharmaceutical composition useful for treating inflammation in a mammalian specie comprising as the active ingredient from about 1 mg./kg. to about 30 mg./kg. of a compound or mixture of compounds of claim 1 and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
20 words
The method of treating inflammation in a mammalian specie comprising administering an effective amount of the composition of claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-18 | 1982-03-20 | 1982-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-18 | 1986-03-20 | 1986-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-18 | 1990-03-20 | 1990-09-19 | $7700.00 | Window Closed / Lapsed |