Pharmaceutical composition containing prostadienoic acid for regulating gastric secretion
Abstract
Abstract Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R 1 is hydrogen or lower alkyl; R 2 and R 6 are hydrogen when Y is a single bond and R 2 and R 6 are absent when Y is a double bond; R 3 is keto, ##STR2## R' 9 is hydrogen or lower alkyl; R' 10 is lower alkyl; R' 11 is lower alkyl; Z 1 is cis or trans --CH═CH-- or --CH 2 CH 2 --; Z 2 is trans --CH═CH-- or --CH 2 CH 2 --; X is a single bond or a double bond and X is a single bond when R 4 and R 5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion. The compounds are also useful as platelet anti-clumping agents and for the inhibition of peptic ulcers.
Inventors
- 👤 Ned M. Weinshenker
- 👤 Niels H. Anderson
Bibliographic Details
Claims Analysis
Total Claims: 4References Cited (Backward Citations)
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