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US4113726A Expired / Lapsed US ⏱️ 0.0 years remaining

Perhydrofluorenetetrol and perhydrophenanthrenetetrol derivatives

Assignee: ER Squibb and Sons LLC
•
Filing: 1974-02-28
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Granted: 1978-09-12
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Expires: 1994-02-28
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Abstract

Abstract Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n 1 is 0, 1 or 2 and n 2 is 0, 1, 2 or 3, R 1 , R 2 , R 3 and R 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R 8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R 9 O(CH 2 )q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Inventors

  • 👤 Frederic Peter Hauck
  • 👤 Christopher Michael Cimarusti

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 13:58
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185; C07C; C07C17/00; C07C17/093; C07C17/16; C07C57/00; C07C57/30; C07C57/38; C07C57/40; C07C61/00; C07C61/16; C07C61/28; C07C61/29; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/20; C07D211/22; C07D211/36; C07D211/60; C07D295/04; C07D295/08; C07D295/096; C07D307/00; C07D307/77; C07D307/93; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/06; C07C2603/10; C07C2603/12; C07C2603/18; C07C2603/22; C07C2603/26

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 244 words
A compound of the structure ##STR240## wherein n is 1 or 2; n 1 is 0, 1 or 2; n 2 is 0, 1, 2 or 3; p is an integer of from 0 to 10; R is lower alkyl, lower alkoxy, or cycloalkyl; R 8 is hydrogen, lower alkyl, cycloalkyl, di-lower alkylamino-lower alkyl, hydroxy or R 9 O(CH 2 ) q -; q is an integer of from 1 to 10; R 9 is hydrogen, an acyl radical having less than 12 carbon atoms selected from the group consisting of lower alkanoyl, lower alkenoyl, monocyclic aroyl, monocyclic aryl-lower alkanoyl, cycloalkanoyl, cycloalkenoyl, cycloalkyl-lower alkanoyl and cycloalkenyl-lower alkanoyl, lower alkyl, halo-lower alkyl, lower alkoxy-carbonyl, amido or lower alkoxy-alkylene; Y is ##STR241## wherein R 5 and R 6 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halo-lower alkyl, monocyclic cycloalkyl, monocyclic cycloalkyl-lower alkyl, lower alkanoyl, halo-lower alkanoyl, hydroxy-lower alkyl, monocyclic aryloyl, monocyclic aryl, or monocyclic aryl-lower alkyl; or ##STR242## can be taken together to form a 5-, 6- or 7-membered nitrogen heterocyclic radical containing not more than one hetero atom in addition to the nitrogen atom, wherein said additional hetero atom may be oxygen, nitrogen, or sulfur; wherein the term cycloalkyl refers to cycloalkyl groups having 3 to 6 carbon atoms and wherein the term aryl refers to phenyl or phenyl substituted with lower alkyl, halogen, nitro, or lower alkoxy; stereoisomers thereof, acid salts thereof, quaternary salts thereof and N-oxides thereof.
Claim 2
Dependent Claim 244 words
A compound of the structure ##STR240## wherein n is 1 or 2; n 1 is 0, 1 or 2; n 2 is 0, 1, 2 or 3; p is an integer of from 0 to 10; R is lower alkyl, lower alkoxy, or cycloalkyl; R 8 is hydrogen, lower alkyl, cycloalkyl, di-lower alkylamino-lower alkyl, hydroxy or R 9 O(CH 2 ) q -; q is an integer of from 1 to 10; R 9 is hydrogen, an acyl radical having less than 12 carbon atoms selected from the group consisting of lower alkanoyl, lower alkenoyl, monocyclic aroyl, monocyclic aryl-lower alkanoyl, cycloalkanoyl, cycloalkenoyl, cycloalkyl-lower alkanoyl and cycloalkenyl-lower alkanoyl, lower alkyl, halo-lower alkyl, lower alkoxy-carbonyl, amido or lower alkoxy-alkylene; Y is ##STR241## wherein R 5 and R 6 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halo-lower alkyl, monocyclic cycloalkyl, monocyclic cycloalkyl-lower alkyl, lower alkanoyl, halo-lower alkanoyl, hydroxy-lower alkyl, monocyclic aryloyl, monocyclic aryl, or monocyclic aryl-lower alkyl; or ##STR242## can be taken together to form a 5-, 6- or 7-membered nitrogen heterocyclic radical containing not more than one hetero atom in addition to the nitrogen atom, wherein said additional hetero atom may be oxygen, nitrogen, or sulfur; wherein the term cycloalkyl refers to cycloalkyl groups having 3 to 6 carbon atoms and wherein the term aryl refers to phenyl or phenyl substituted with lower alkyl, halogen, nitro, or lower alkoxy; stereoisomers thereof, acid salts thereof, quaternary salts thereof and N-oxides thereof.
Claim 3
Dependent Claim 11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 4
Dependent Claim 11 words
A compound in accordance with claim 1 wherein n is 2.

References Cited (Backward Citations)

DE2145154A1 Cited
US3751420A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1981-09-11 1982-03-13 1982-09-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1985-09-11 1986-03-13 1986-09-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1989-09-11 1990-03-13 1990-09-12 $7700.00 Window Closed / Lapsed

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