Methods of use of pyridylalkyl phenylthioureas

Claim 1

A method for increasing the production of endogenous prostaglandins by a mammal which comprises administering to said mammal an effective amount of a compound of the formula: ##STR13## a pyridyl N-oxide thereof and a pharmaceutically acceptable acid addtion salt thereof wherein R 1 and R 2 are each hydrogen, halogen, alkyl of one to six carbon atoms, inclusive, alkenyl of two to six carbon atoms, inclusive, cycloalkyl of three to six carbon atoms, inclusive, phenyl, alkoxy of one to 12 carbon atoms, inclusive, alkylthio of one to 12 carbon atoms, inclusive, nitro, amino, alkylamino with alkyl of one to 12 carbon atoms, inclusive, dialkylamino with each alkyl of one to 12 carbon atoms, inclusive, alkanoylamine with alkyl of one to 12 carbon atoms, inclusive, or trihalomethyl; R 3 and R 4 are each hydrogen, alkyl of one to four carbon atoms, inclusive, cycloalkyl of three to eight carbon atoms, inclusive, aryl of six to 12 carbon atoms, inclusive, aralkyl of seven to 12 carbon atoms, inclusive, and aryl of six to 12 carbon atoms, inclusive, said aryl substituted with halogen, alkoxy of one to four carbon atoms, inclusive, halogen substituted alkyl of one to four carbon atoms, inclusive, and halogen substituted alkoxy of one to four carbon atoms, inclusive; R 5 is hydrogen, halogen, alkyl of one to 12 carbon atoms, inclusive, alkenyl of two to 12 carbon atoms, inclusive, cycloalkyl of three to eight carbon atoms, inclusive, aryl of six to 12 carbon atoms, inclusive, aralkyl of seven to 12 carbon atoms, inclusive, alkoxy of one to 12 carbon atoms, inclusive, and halogen substituted alkyl of one to 12 carbon atoms, inclusive, halogen substituted alkenyl of two to 12 carbon atoms, inclusive, halogen substituted cycloalkyl of three to eight carbon atoms, inclusive, halogen substituted aryl of six to 12 carbon atoms, inclusive, and halogen substituted aralkyl of seven to 12 carbon atoms, inclusive; R 6 and R 7 are each nitro, amino, alkanoylamino with alkyl of one to 12 carbon atoms, inclusive, alkylamino with alkyl of one to 12 carbon atoms, inclusive, dialkylamino with each alkyl of one to 12 carbon atoms, inclusive, alkylthio with alkyl of one to 12 carbon atoms, inclusive, arylthio of six to 12 carbon atoms, inclusive, aryloxy of six to 12 carbon atoms, inclusive, and a group R 5 as previously defined; and n is an integer of from one to two, inclusive.

Claim 2

A method for increasing the production of endogenous prostaglandins by a mammal which comprises administering to said mammal an effective amount of a compound of the formula: ##STR13## a pyridyl N-oxide thereof and a pharmaceutically acceptable acid addtion salt thereof wherein R 1 and R 2 are each hydrogen, halogen, alkyl of one to six carbon atoms, inclusive, alkenyl of two to six carbon atoms, inclusive, cycloalkyl of three to six carbon atoms, inclusive, phenyl, alkoxy of one to 12 carbon atoms, inclusive, alkylthio of one to 12 carbon atoms, inclusive, nitro, amino, alkylamino with alkyl of one to 12 carbon atoms, inclusive, dialkylamino with each alkyl of one to 12 carbon atoms, inclusive, alkanoylamine with alkyl of one to 12 carbon atoms, inclusive, or trihalomethyl; R 3 and R 4 are each hydrogen, alkyl of one to four carbon atoms, inclusive, cycloalkyl of three to eight carbon atoms, inclusive, aryl of six to 12 carbon atoms, inclusive, aralkyl of seven to 12 carbon atoms, inclusive, and aryl of six to 12 carbon atoms, inclusive, said aryl substituted with halogen, alkoxy of one to four carbon atoms, inclusive, halogen substituted alkyl of one to four carbon atoms, inclusive, and halogen substituted alkoxy of one to four carbon atoms, inclusive; R 5 is hydrogen, halogen, alkyl of one to 12 carbon atoms, inclusive, alkenyl of two to 12 carbon atoms, inclusive, cycloalkyl of three to eight carbon atoms, inclusive, aryl of six to 12 carbon atoms, inclusive, aralkyl of seven to 12 carbon atoms, inclusive, alkoxy of one to 12 carbon atoms, inclusive, and halogen substituted alkyl of one to 12 carbon atoms, inclusive, halogen substituted alkenyl of two to 12 carbon atoms, inclusive, halogen substituted cycloalkyl of three to eight carbon atoms, inclusive, halogen substituted aryl of six to 12 carbon atoms, inclusive, and halogen substituted aralkyl of seven to 12 carbon atoms, inclusive; R 6 and R 7 are each nitro, amino, alkanoylamino with alkyl of one to 12 carbon atoms, inclusive, alkylamino with alkyl of one to 12 carbon atoms, inclusive, dialkylamino with each alkyl of one to 12 carbon atoms, inclusive, alkylthio with alkyl of one to 12 carbon atoms, inclusive, arylthio of six to 12 carbon atoms, inclusive, aryloxy of six to 12 carbon atoms, inclusive, and a group R 5 as previously defined; and n is an integer of from one to two, inclusive.

Claim 21

A method of increasing the production of endogenous prostaglandins by a mammal which comprises administering to said mammal an effective amount of a compound selected from those of formula: ##STR14## pyridyl N-oxides thereof and the pharmaceutically acceptable acid addition salts thereof wherein X is selected from hydrogeon, halogen, nitro, and trihalomethyl.

Claim 22

A method of increasing the production of endogenous prostaglandins by a mammal which comprises administering to said mammal an effective amount of a compound selected from those of formula: ##STR14## pyridyl N-oxides thereof and the pharmaceutically acceptable acid addition salts thereof wherein X is selected from hydrogeon, halogen, nitro, and trihalomethyl.