US4112092A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Naphthylmethyl-4-(thiazolyl-2)-piperazines
Assignee: Science Union et Cie
•
Filing: 1977-04-08
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Granted: 1978-09-05
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Expires: 1997-04-08
Abstract
Abstract Naphthyl derivatives of the formula: <IMAGE> wherein:
Inventors
- 👤 Gilbert Regnier
- 👤 Roger Canevari
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:17
CPC Classifications
C; C07; C07D; C07D417/00; C07D417/02; C07D417/04; A; A61; A61P; A61P25/00; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
115 words
A compound selected from the group consisting of: (A) naphthyl compounds of the formula I: ##STR9## wherein: R 1 is selected from the group consisting of hydrogen, halogen, i.e. chlorine, fluorine, or bromine, lower-alkyl and lower-alkoxy, each having 1 to 5 carbon atoms inclusive, R 2 and R 3 , which are the same or different, are selected from the group consisting of hydrogen, lower-alkyl having 1 to 5 carbon atoms inclusive and phenyl and R 2 and R 3 joined together are --CH ═ CH -- CH ═ CH -- in order to form with the thiazolyl radical to which they are bonded a benzothiazolyl radical; and (B) physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
115 words
A compound selected from the group consisting of: (A) naphthyl compounds of the formula I: ##STR9## wherein: R 1 is selected from the group consisting of hydrogen, halogen, i.e. chlorine, fluorine, or bromine, lower-alkyl and lower-alkoxy, each having 1 to 5 carbon atoms inclusive, R 2 and R 3 , which are the same or different, are selected from the group consisting of hydrogen, lower-alkyl having 1 to 5 carbon atoms inclusive and phenyl and R 2 and R 3 joined together are --CH ═ CH -- CH ═ CH -- in order to form with the thiazolyl radical to which they are bonded a benzothiazolyl radical; and (B) physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
8 words
A compound of claim 1 which is 1-(2-naphthylmethyl)-4-(2-thiazolyl)-piperazine.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is 1-(1-naphthylmethyl)-4-(2-thiazolyl)-piperazine.
Claim 5
Dependent Claim
8 words
A compound of claim 1 which is 1-(7-methyl-1-naphthylmethyl)-4-(2thiazolyl)-piperazine.
Claim 6
Dependent Claim
31 words
A pharmaceutical composition useful for treating CNS disorders containing as active ingredient a compound of claim 1 in an amount of 15 to 150 mg, together with a suitable pharmaceutical carrier.
Claim 7
Dependent Claim
38 words
A method for treating a living animal body afflicted with a disorder of the central nervous system, comprising the step of administering a compound of claim 1 in an amount effective for the alleviation of the said condition.
References Cited (Backward Citations)
US3941789A
Cited
US3944551A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |