US4112075A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Furanose-O-pyridylcarboxylic acid esters
Assignee: Novartis Corp
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Filing: 1976-09-09
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Granted: 1978-09-05
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Expires: 1996-09-09
Abstract
Abstract The invention relates to furanose-O-pyridylcarboxylic acid esters, such as the ethyl-2-O-methyl-3,5,6-tri-O-nicotinoyl-D-glucofuranoside, which have anti-inflammatory activity and are fibrinolysis activators. They can be used for the treatment of rheumatic and neuralgic complaints, and especially for the topical percutaneous treatment of localized inflammatory processes.
Inventors
- 👤 Gerhard Baschang
- 👤 Alex Sele
- 👤 Jaroslav Stanek
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 14:07
CPC Classifications
C; C07; C07H; C07H9/00; C07H9/02; C07H9/04; A; A61; A61P; A61P29/00; C07H13/00; C07H13/02; C07H13/10; C07H15/00; C07H15/02; C07H15/04; C07H15/18
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
75 words
A furanose-O-pyridylcarboxylic acid ester of the formula I ##STR3## in which at least one of R 1 , R 2 , R 3 , R 5 and R 6 is pyridylcarbonyl and the remainder of R 1 , R 2 , R 3 , R 5 and R 6 are lower alkyl, lower alkenyl, phenyl-lower alkyl, halogenophenyl-lower alkyl, trifluoromethylphenyl-lower alkyl, lower alkylphenyl-lower alkyl, lower alkoxyphenyl-lower alkyl or hydrogen, or in which OR 1 is hydrogen.
Claim 2
Dependent Claim
75 words
A furanose-O-pyridylcarboxylic acid ester of the formula I ##STR3## in which at least one of R 1 , R 2 , R 3 , R 5 and R 6 is pyridylcarbonyl and the remainder of R 1 , R 2 , R 3 , R 5 and R 6 are lower alkyl, lower alkenyl, phenyl-lower alkyl, halogenophenyl-lower alkyl, trifluoromethylphenyl-lower alkyl, lower alkylphenyl-lower alkyl, lower alkoxyphenyl-lower alkyl or hydrogen, or in which OR 1 is hydrogen.
Claim 3
Dependent Claim
75 words
A compound as claimed in claim 1 of the formula I, in which 1-4 of R 1 , R 2 , R 3 , R 5 and R 6 are pyridylcarbonyl and the remainder of R 1 , R 2 , R 3 , R 5 and R 6 are lower alkyl, lower alkenyl, phenl-lower alkyl, halogenophenyl-lower alkyl, trifluoromethylphenyl-lower alkyl, lower alkylphenyl-lower alkyl, lower alkoxyphenyl-lower alkyl or hydrogen, or in which OR 1 is hydrogen.
Claim 4
Dependent Claim
68 words
A compound as claimed in claim 1 of the formula I, in which 1-4 of R 1 , R 2 , R 3 , R 5 and R 6 are pyridylcarbonyl and the remainder of R 1 , R 2 , R 3 , R 5 and R 6 are lower alkyl, lower alkenyl, benzyl, halogenobenzyl, trifluoromethylbenzyl, lower alkylbenzyl, lower alkoxybenzyl or hydrogen, or OR 1 is hydrogen.
Claim 5
Dependent Claim
65 words
A compound as claimed in claim 1 of the formula I, in which 1-4 of R 1 , R 2 , R 3 , R 5 and R 6 are pyridylcarbonyl and the remainder of R 1 , R 2 , R 3 , R 5 and R 6 are lower alkyl with 1-3 C atoms, benzyl, chlorobenzyl or hydrogen, or OR 1 is hydrogen.
Claim 6
Dependent Claim
64 words
A compound as claimed in claim 1 of the formula I, in which 1-4 of R 2 , R 3 , R 5 and R 6 are pyridylcarbonyl and the remainder of R 2 , R 3 , R 5 and R 6 are lower alkyl with 1-3 C atoms, benzyl, chlorobenzyl or hydrogen and R 1 is lower alkyl with 1-3 C atoms.
Claim 7
Dependent Claim
36 words
A compound as claimed in claim 1 of the formula II ##STR4## wherein R 1 is ethyl, R 3 , R 5 and R 6 each represent 3-pyridylcarbonyl and R 2 is hydrogen, methyl or 3-pyridylcarbonyl.
Claim 8
Dependent Claim
35 words
A compound as claimed in claim 6 of the formula II wherein R 1 is ethyl, R 3 , R 5 and R 6 each represent benzyl and R 2 is 2-, 3- or 4-pyridylcarbonyl.
Claim 9
Dependent Claim
34 words
A compound as claimed in claim 6 of the formula II, wherein R 1 is ethyl, R 2 is hydrogen, R 3 is 4-pyridylcarbonyl or n-propyl and R 5 and R 6 represent 4-pyridylcarbonyl.
Claim 10
Dependent Claim
35 words
A compound as claimed in claim 6 of the formula II, wherein R 1 is ethyl, R 2 is 3-pyridylcarbonyl, R 3 is lower alkyl and R 5 and R 6 are benzyl or p-chlorobenzyl.
Claim 11
Dependent Claim
20 words
A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 together with a pharmaceutically usable excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |