US4112072A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Resuspendable dried antacids
Assignee: Reheis Co Inc
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Filing: 1973-12-10
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Granted: 1978-09-05
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Expires: 1993-12-10
Abstract
Abstract Antacid compositions prepared by drying a wet, compressed aluminum hydroxide gel to solid form which are capable of being readily resuspended to yield an opaque, aqueous suspension which reflects the properties of the original compressed gel, are produced by codrying a hydrous, gelatinous aluminum hydroxide material with a di- or trihydroxy alcohol.
Inventors
- 👤 Andrew M. Rubino
- 👤 Jack J. Margres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:50
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/10
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
150 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original compressed gel, comprising the codried combination of a hydrous gelatinous aluminum hydroxide material selected from the group consisting of (1) basic aluminum bicarbonate-carbonate, (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and a water soluble food-grade di- or trihydroxy alcohol suitable for oral ingestion, wherein analysis of the dried product yields a figure in the range of from 30-60 percent by weight for the sum of aluminum hydroxide and magnesium hydroxide calculatd as Al 2 O 3 and MgO and shows that there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 .
Claim 2
Dependent Claim
150 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original compressed gel, comprising the codried combination of a hydrous gelatinous aluminum hydroxide material selected from the group consisting of (1) basic aluminum bicarbonate-carbonate, (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and a water soluble food-grade di- or trihydroxy alcohol suitable for oral ingestion, wherein analysis of the dried product yields a figure in the range of from 30-60 percent by weight for the sum of aluminum hydroxide and magnesium hydroxide calculatd as Al 2 O 3 and MgO and shows that there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 .
Claim 3
Dependent Claim
24 words
The antacid composition of claim 1, wherein said dried product contains in the range of about 5-50 percent by weight of said food-grade alcohol.
Claim 4
Dependent Claim
13 words
The antacid composition of claim 1, wherein the food-grade alcohol is propylene glycol.
Claim 5
Dependent Claim
12 words
The antacid composition of claim 1, wherein the food-grade alcohol is glycerin.
Claim 6
Dependent Claim
14 words
The antacid composition of claim 1, wherein the food-grade alcohol is 1,3 butylene glycol.
Claim 7
Dependent Claim
100 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original compressed gel, comprising, the codried combination of a compressed aluminum hydroxy bicarbonate-carbonate gel and a water soluble food-grade di- or trihydroxy alcohol suitable for oral ingestion, wherein the dried product contains from 40-50 percent Al 2 O 3 , from 20-30 percent food-grade alcohol and contains at least 0.3 mol of carbonate calculated as CO 2 for each mole of Al 2 O 3 .
Claim 8
Dependent Claim
100 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original compressed gel, comprising, the codried combination of a compressed aluminum hydroxy bicarbonate-carbonate gel and a water soluble food-grade di- or trihydroxy alcohol suitable for oral ingestion, wherein the dried product contains from 40-50 percent Al 2 O 3 , from 20-30 percent food-grade alcohol and contains at least 0.3 mol of carbonate calculated as CO 2 for each mole of Al 2 O 3 .
Claim 9
Independent Claim
133 words
A method for manufacturing an antacid composition in solid form comprising mixing from 1 to 25 parts by weight of a hydrous gelatinous aluminum hydroxide material with one part by weight of a water soluble di- or trihydroxy alcohol suitable for oral ingestion and drying the aqueous mixture to produce a dried product wherein the sum of aluminum hydroxide and any magnesium hydroxide present calculated as Al 2 O 3 and MgO, is in the range of from 30-60 percent by weight and there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 , whereby said product is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original hydrous gelatinous aluminum hydroxide material.
Claim 10
Independent Claim
133 words
A method for manufacturing an antacid composition in solid form comprising mixing from 1 to 25 parts by weight of a hydrous gelatinous aluminum hydroxide material with one part by weight of a water soluble di- or trihydroxy alcohol suitable for oral ingestion and drying the aqueous mixture to produce a dried product wherein the sum of aluminum hydroxide and any magnesium hydroxide present calculated as Al 2 O 3 and MgO, is in the range of from 30-60 percent by weight and there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 , whereby said product is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original hydrous gelatinous aluminum hydroxide material.
Claim 11
Dependent Claim
32 words
The method of claim 7 wherein said hydrous, gelatinous aluminum hydroxide material is selected from the group consisting of basic aluminum bicarbonate-carbonate, magnesium basic carbonate, magnesium hydroxide, magnesium trisilicate, and mixtures thereof.
Claim 12
Dependent Claim
25 words
The method of claim 7 wherein said dried product contains in the range of about 15-35 percent by weight of said di- or trihydroxy alcohol.
Claim 13
Dependent Claim
11 words
The method of claim 7 wherein said alcohol is propylene glycol.
Claim 14
Dependent Claim
10 words
The method of claim 7 wherein said alcohol is glycerin.
Claim 15
Dependent Claim
12 words
The method of claim 7 wherein said alcohol is 1,3 butylene glycol.
Claim 16
Dependent Claim
14 words
The method of claim 7 wherein said aqueous mixture is dried by spray drying.
Claim 17
Dependent Claim
35 words
The method of claim 7 wherein said hydrous, gelatinous aluminum hydroxide material contains from 1 to 20 parts by weight of compressed aluminum hydroxide gel and from 1 to 5 parts by weight of water.
Claim 18
Dependent Claim
12 words
The method of claim 7 wherein said aqueous mixture is tray dried.
Claim 19
Dependent Claim
15 words
The method of claim 7 wherein said opaque mixture is dried in a drum drier.
Claim 20
Dependent Claim
149 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original gel, comprising the codried combination of a hydrous gelatinous aluminum hydroxide material selected from the group consisting of (1) basic aluminum bicarbonate-carbonate, (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and polyethylene glycol having a molecular weight of from about 200 to 700, wherein analysis of the dried product yields a figure in the range of from 30-60 percent by weight for the sum of aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 .
Claim 21
Dependent Claim
149 words
An antacid composition prepared by drying a wet compressed aluminum hydroxide gel to solid form, which is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original gel, comprising the codried combination of a hydrous gelatinous aluminum hydroxide material selected from the group consisting of (1) basic aluminum bicarbonate-carbonate, (2) basic aluminum bicarbonate-carbonate in combination with magnesium basic carbonate, magnesium hydroxide, or magnesium trisilicate, or mixtures thereof, and polyethylene glycol having a molecular weight of from about 200 to 700, wherein analysis of the dried product yields a figure in the range of from 30-60 percent by weight for the sum of aluminum hydroxide and magnesium hydroxide calculated as Al 2 O 3 and MgO and shows that there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 .
Claim 22
Independent Claim
129 words
A method for manufacturing an antacid composition in solid form comprising mixing from 1 to 25 parts by weight of a hydrous gelatinous aluminum hydroxide material with one part by weight of polyethylene glycol having a molecular weight of from about 200 to 700 to produce a dried product wherein the sum of aluminum hydroxide and any magnesium hydroxide present calculated as Al 2 O 3 and MgO, is in the range of from 30-60 percent by weight and there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 , whereby said product is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original hydrous gelatinous aluminum hydroxide material.
Claim 23
Independent Claim
129 words
A method for manufacturing an antacid composition in solid form comprising mixing from 1 to 25 parts by weight of a hydrous gelatinous aluminum hydroxide material with one part by weight of polyethylene glycol having a molecular weight of from about 200 to 700 to produce a dried product wherein the sum of aluminum hydroxide and any magnesium hydroxide present calculated as Al 2 O 3 and MgO, is in the range of from 30-60 percent by weight and there is also present at least 0.3 mol of carbonate calculated as CO 2 for each mol of Al 2 O 3 , whereby said product is capable of being readily resuspended to yield an opaque aqueous suspension which reflects the properties of the original hydrous gelatinous aluminum hydroxide material.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |